Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| T47D | Vorinostat | HDAC | Misc | 1.8007 | -0.1567 | 0.1750 | 0.0409 | 2.2684 | 2.0704 | 0.99157 |
| T47D | TGX221 | PI3Kb | PI3K/mTOR | Inf | 0.7986 | -0.0066 | -0.0002 | 2.2233 | 4.3807 | 0.7868 |
| T47D | Doxorubicin | Chemo | Chemotherapy | 0.0018887 | -0.3611 | 0.9189 | 0.1014 | 1.2268 | 0.0024801 | 0.96538 |
| T47D | ABT-737 | Bcl2/XL | Misc | 12.2023 | 0.5888 | 0.0010 | 0.0084 | 2.2890 | 9.7541 | 0.92156 |
| T47D | Bleomycin | Radiation | Misc | 0.19877 | -0.0840 | 0.4615 | 0.0190 | 0.9701 | 0.24632 | 0.9812 |
| T47D | Taselisib | PI3Ka, g, d | PI3K/mTOR | 0.0017858 | -0.1047 | 0.8990 | 0.0550 | 1.1740 | 0.0018197 | 0.97255 |
| T47D | AZD7762 | CHK1/2 | Cell cycle | 2.3432 | -0.0573 | 0.1322 | 0.0195 | 2.6709 | 2.4809 | 0.98871 |
| T47D | Cisplatin | Chemo | Chemotherapy | 1.5698 | 0.1019 | 0.2147 | 0.0055 | 1.3290 | 1.5705 | 0.98121 |
| T47D | Etoposide | Topo II | Chemotherapy | 0.041662 | -0.1861 | 0.6661 | 0.0533 | 1.1976 | 0.051932 | 0.98563 |
| T47D | Saracatinib | SRC | MAPK/nRTK | 3.9647 | 0.3892 | 0.1722 | 0.0087 | 0.6928 | 1.6318 | 0.9752 |
| T47D | A-1210477 | Mcl-1 | Misc | Inf | 0.5752 | 0.0227 | 0.0055 | 5.0000 | 3.7781 | 0.96287 |
| T47D | Olaparib | PARP | Misc | Inf | 0.5304 | 0.0302 | 0.0015 | 4.9632 | 3.5388 | 0.95841 |
| T47D | Ipatasertib | AKT | PI3K/mTOR | 0.13653 | 0.1331 | 0.4303 | 0.0112 | 1.0853 | 0.10541 | 0.99474 |
| T47D | Alpelisib | PI3Ka | PI3K/mTOR | 0.15284 | -0.0332 | 0.4568 | 0.0181 | 0.7816 | 0.17573 | 0.98947 |
| T47D | Abemaciclib | CDK4/6 | Cell cycle | 0.0042816 | -0.0412 | 0.7664 | 0.0265 | 1.3858 | 0.0037683 | 0.95899 |
| T47D | Palbociclib | CDK4/6 | Cell cycle | 0.027507 | 0.1166 | 0.4501 | 0.0077 | 1.5536 | 0.022367 | 0.99262 |
| T47D | Volasertib | PLK | Cell cycle | 0.031411 | -0.1585 | 0.3959 | 0.0580 | 1.7544 | 0.036365 | 0.99393 |
| T47D | Dinaciclib | pan CDK | Cell cycle | 0.019853 | -0.2109 | 0.4815 | 0.0484 | 5.0000 | 0.021113 | 0.99494 |
| T47D | Taxol | Chemo | Chemotherapy | 0.0035285 | -0.1337 | 0.6636 | 0.2505 | 2.2353 | 0.0038792 | 0.99665 |
| T47D | Topotecan | Topo I | Chemotherapy | 0.0052275 | -0.1971 | 0.9594 | 0.1261 | 1.3094 | 0.0068541 | 0.99083 |
| T47D | Dasatinib | BCR/ABL | MAPK/nRTK | 12.5697 | 0.4961 | 0.1933 | 0.0086 | 0.2753 | 679.7315 | 0.95229 |
| T47D | Trametinib | MEK | MAPK/nRTK | Inf | 0.5801 | 0.2130 | 0.0041 | 0.9941 | 0.0048584 | 0.90394 |
| T47D | Luminespib | HSP90 | Misc | 0.0060689 | 0.0212 | 0.5165 | 0.0278 | 4.3267 | 0.0059347 | 0.99479 |
| T47D | Everolimus | mTOR1 | PI3K/mTOR | -Inf | 0.2975 | 0.6157 | 0.0150 | 0.1000 | 5.9599e-07 | 0.77906 |
| T47D | Torin2 | mTOR/ATM/ATR | PI3K/mTOR | 0.0060179 | 0.0099 | 0.5239 | 0.0218 | 1.4244 | 0.0056296 | 0.99382 |