Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 Sirolimus 2 72
0.032
 1934.0 2971.8 690.5
-1.49
 0.631 0.651 2.105
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
0.1
 1934.5 2971.8 690.5
-1.0
 0.631 0.651 2.105
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
0.32
 1940.5 2971.8 690.5
-0.495
 0.633 0.653 2.105
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
1.0
 1847.0 2971.8 690.5
0.0
 0.596 0.622 2.105
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
3.2
 1829.3 2971.8 690.5
0.505
 0.588 0.616 2.105
HCC38 Rapamycin 0 2 72
HCC38 TGX221 2 72
0.001
 2867.3 2993.0 690.5
-3.0
 0.960 0.958 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
0.0032
 3028.5 2993.0 690.5
-2.49
 1.010 1.010 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
0.01
 2993.3 2993.0 690.5
-2.0
 1.000 1.000 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
0.032
 2997.0 2993.0 690.5
-1.49
 1.000 1.000 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
0.1
 2850.0 2993.0 690.5
-1.0
 0.954 0.952 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
0.32
 2867.5 2993.0 690.5
-0.495
 0.960 0.958 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
1.0
 2816.5 2993.0 690.5
0.0
 0.943 0.941 2.116
HCC38 TGX221 0 2 72
HCC38 TGX221 2 72
3.2
 2709.3 2993.0 690.5
0.505
 0.908 0.905 2.116
HCC38 TGX221 0 2 72
HCC38 Torin1 2 72
0.001
 2898.0 3034.5 690.5
-3.0
 0.957 0.955 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
0.0032
 2499.0 3034.5 690.5
-2.49
 0.826 0.824 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
0.01
 2047.8 3034.5 690.5
-2.0
 0.664 0.675 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
0.032
 1480.5 3034.5 690.5
-1.49
 0.429 0.488 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
0.1
 1146.3 3034.5 690.5
-1.0
 0.268 0.378 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
0.32
 974.3 3034.5 690.5
-0.495
 0.175 0.321 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
1.0
 895.5 3034.5 690.5
0.0
 0.129 0.295 2.136
HCC38 Torin1 0 2 72
HCC38 Torin1 2 72
3.2
 749.8 3034.5 690.5
0.505
 0.039 0.247 2.136
HCC38 Torin1 0 2 72
HCC38 Torin2 2 72
0.001
 2849.5 3044.5 690.5
-3.0
 0.939 0.936 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
0.0032
 2222.3 3044.5 690.5
-2.49
 0.726 0.730 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
0.01
 1678.5 3044.5 690.5
-2.0
 0.514 0.551 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
0.032
 1258.8 3044.5 690.5
-1.49
 0.324 0.413 2.140
HCC38 Torin2 0 2 72