Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 Torin2 2 72
0.1
 847.0 3044.5 690.5
-1.0
 0.100 0.278 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
0.32
 524.3 3044.5 690.5
-0.495
 -0.121 0.172 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
1.0
 295.3 3044.5 690.5
0.0
 -0.328 0.097 2.140
HCC38 Torin2 0 2 72
HCC38 Torin2 2 72
3.2
 170.5 3044.5 690.5
0.505
 -0.480 0.056 2.140
HCC38 Torin2 0 2 72
HCC38 Trametinib 2 72
0.001
 2720.8 3029.5 690.5
-3.0
 0.902 0.898 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
0.0032
 2506.5 3029.5 690.5
-2.49
 0.830 0.827 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
0.01
 2386.8 3029.5 690.5
-2.0
 0.788 0.788 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
0.032
 2163.8 3029.5 690.5
-1.49
 0.708 0.714 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
0.1
 1950.0 3029.5 690.5
-1.0
 0.627 0.644 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
0.32
 1481.8 3029.5 690.5
-0.495
 0.430 0.489 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
1.0
 1229.5 3029.5 690.5
0.0
 0.311 0.406 2.133
HCC38 Trametinib 0 2 72
HCC38 Trametinib 2 72
3.2
 1143.3 3029.5 690.5
0.505
 0.267 0.377 2.133
HCC38 Trametinib 0 2 72
HCC38 WYE-125132 2 72
0.001
 2871.8 3050.0 690.5
-3.0
 0.945 0.942 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.0032
 2749.3 3050.0 690.5
-2.49
 0.905 0.901 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.01
 2479.3 3050.0 690.5
-2.0
 0.816 0.813 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.032
 1949.0 3050.0 690.5
-1.49
 0.623 0.639 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.1
 1414.8 3050.0 690.5
-1.0
 0.398 0.464 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
0.32
 1061.0 3050.0 690.5
-0.495
 0.222 0.348 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
1.0
 985.5 3050.0 690.5
0.0
 0.181 0.323 2.143
HCC38 WYE125132 0 2 72
HCC38 WYE-125132 2 72
3.2
 929.8 3050.0 690.5
0.505
 0.149 0.305 2.143
HCC38 WYE125132 0 2 72
HCC38 XL147 2 72
0.001
 2998.5 3158.8 690.5
-3.0
 0.953 0.949 2.194
HCC38 XL147 0 2 72
HCC38 XL147 2 72
0.0032
 3022.3 3158.8 690.5
-2.49
 0.960 0.957 2.194
HCC38 XL147 0 2 72
HCC38 XL147 2 72
0.01
 3103.3 3158.8 690.5
-2.0
 0.984 0.982 2.194
HCC38 XL147 0 2 72
HCC38 XL147 2 72
0.032
 3000.0 3158.8 690.5
-1.49
 0.954 0.950 2.194
HCC38 XL147 0 2 72
HCC38 XL147 2 72
0.1
 3083.3 3158.8 690.5
-1.0
 0.978 0.976 2.194
HCC38 XL147 0 2 72