Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | ZSTK474 | 3 | 72 | 0.32 | 2743.5 | 3243.8 | 1180.5 | -0.495 | 0.783 | 0.846 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 1.0 | 2470.8 | 3243.8 | 1180.5 | 0.0 | 0.659 | 0.762 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 3.2 | 1923.8 | 3243.8 | 1180.5 | 0.505 | 0.398 | 0.593 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC70 | AS605240 | 1 | 72 | 0.001 | 3232.5 | 3347.8 | 1279.8 | -3.0 | 0.950 | 0.966 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.0032 | 3284.0 | 3347.8 | 1279.8 | -2.49 | 0.972 | 0.981 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.01 | 3372.3 | 3347.8 | 1279.8 | -2.0 | 1.010 | 1.010 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.032 | 3436.8 | 3347.8 | 1279.8 | -1.49 | 1.040 | 1.030 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.1 | 3016.3 | 3347.8 | 1279.8 | -1.0 | 0.855 | 0.901 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 0.32 | 2661.3 | 3347.8 | 1279.8 | -0.495 | 0.695 | 0.795 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 1.0 | 2458.0 | 3347.8 | 1279.8 | 0.0 | 0.601 | 0.734 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AS605240 | 1 | 72 | 3.2 | 2219.5 | 3347.8 | 1279.8 | 0.505 | 0.487 | 0.663 | 1.387 | HCC70 AS605240 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.001 | 3327.3 | 3304.5 | 1279.8 | -3.0 | 1.010 | 1.010 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.0032 | 3020.0 | 3304.5 | 1279.8 | -2.49 | 0.873 | 0.914 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.01 | 2660.3 | 3304.5 | 1279.8 | -2.0 | 0.707 | 0.805 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.032 | 2510.5 | 3304.5 | 1279.8 | -1.49 | 0.636 | 0.760 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.1 | 2145.8 | 3304.5 | 1279.8 | -1.0 | 0.459 | 0.649 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.32 | 1989.0 | 3304.5 | 1279.8 | -0.495 | 0.380 | 0.602 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 1.0 | 1642.3 | 3304.5 | 1279.8 | 0.0 | 0.200 | 0.497 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 3.2 | 1302.3 | 3304.5 | 1279.8 | 0.505 | 0.013 | 0.394 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.001 | 3438.3 | 3237.8 | 1279.8 | -3.0 | 1.090 | 1.060 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.0032 | 3029.3 | 3237.8 | 1279.8 | -2.49 | 0.903 | 0.936 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.01 | 2757.5 | 3237.8 | 1279.8 | -2.0 | 0.774 | 0.852 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.032 | 2327.8 | 3237.8 | 1279.8 | -1.49 | 0.563 | 0.719 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.1 | 2066.3 | 3237.8 | 1279.8 | -1.0 | 0.430 | 0.638 | 1.339 | HCC70 AZD8055 0 1 72 |
| HCC70 | AZD8055 | 1 | 72 | 0.32 | 1832.5 | 3237.8 | 1279.8 | -0.495 | 0.307 | 0.566 | 1.339 | HCC70 AZD8055 0 1 72 |