Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC38 MK2206 2 72
0.01
 3049.0 3083.8 690.5
-2.0
 0.990 0.989 2.159
HCC38 MK2206 0 2 72
HCC38 MK2206 2 72
0.032
 3099.0 3083.8 690.5
-1.49
 1.000 1.000 2.159
HCC38 MK2206 0 2 72
HCC38 MK2206 2 72
0.1
 3000.0 3083.8 690.5
-1.0
 0.975 0.973 2.159
HCC38 MK2206 0 2 72
HCC38 MK2206 2 72
0.32
 2994.3 3083.8 690.5
-0.495
 0.973 0.971 2.159
HCC38 MK2206 0 2 72
HCC38 MK2206 2 72
1.0
 2629.3 3083.8 690.5
0.0
 0.858 0.853 2.159
HCC38 MK2206 0 2 72
HCC38 MK2206 2 72
3.2
 2421.0 3083.8 690.5
0.505
 0.788 0.785 2.159
HCC38 MK2206 0 2 72
HCC38 PI103 2 72
0.001
 2917.5 2947.5 690.5
-3.0
 0.990 0.990 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
0.0032
 2972.5 2947.5 690.5
-2.49
 1.010 1.010 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
0.01
 2941.8 2947.5 690.5
-2.0
 0.998 0.998 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
0.032
 3149.0 2947.5 690.5
-1.49
 1.060 1.070 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
0.1
 2783.3 2947.5 690.5
-1.0
 0.946 0.944 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
0.32
 2158.8 2947.5 690.5
-0.495
 0.724 0.732 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
1.0
 1577.8 2947.5 690.5
0.0
 0.484 0.535 2.094
HCC38 PI103 0 2 72
HCC38 PI103 2 72
3.2
 1058.8 2947.5 690.5
0.505
 0.226 0.359 2.094
HCC38 PI103 0 2 72
HCC38 PIK-93 2 72
0.001
 3053.0 2975.5 690.5
-3.0
 1.020 1.030 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
0.0032
 3154.0 2975.5 690.5
-2.49
 1.060 1.060 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
0.01
 3111.5 2975.5 690.5
-2.0
 1.040 1.050 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
0.032
 3052.5 2975.5 690.5
-1.49
 1.020 1.030 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
0.1
 3153.3 2975.5 690.5
-1.0
 1.060 1.060 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
0.32
 2880.3 2975.5 690.5
-0.495
 0.969 0.968 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
1.0
 2684.8 2975.5 690.5
0.0
 0.905 0.902 2.107
HCC38 PIK93 0 2 72
HCC38 PIK-93 2 72
3.2
 2011.0 2975.5 690.5
0.505
 0.661 0.676 2.107
HCC38 PIK93 0 2 72
HCC38 Sirolimus 2 72
0.001
 2010.5 2971.8 690.5
-3.0
 0.661 0.677 2.106
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
0.0032
 1950.0 2971.8 690.5
-2.49
 0.637 0.656 2.105
HCC38 Rapamycin 0 2 72
HCC38 Sirolimus 2 72
0.01
 1989.0 2971.8 690.5
-2.0
 0.653 0.669 2.105
HCC38 Rapamycin 0 2 72