Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | PIK-93 | 1 | 72 | 0.1 | 5404.5 | 5328.0 | 1554.9 | -1.0 | 1.020 | 1.010 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 0.32 | 5119.3 | 5328.0 | 1554.9 | -0.495 | 0.956 | 0.961 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 1.0 | 4726.8 | 5328.0 | 1554.9 | 0.0 | 0.870 | 0.887 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 3.2 | 3952.5 | 5328.0 | 1554.9 | 0.505 | 0.691 | 0.742 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.001 | 3655.8 | 5477.5 | 1554.9 | -3.0 | 0.601 | 0.667 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.0032 | 3657.8 | 5477.5 | 1554.9 | -2.49 | 0.601 | 0.668 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.01 | 3561.0 | 5477.5 | 1554.9 | -2.0 | 0.578 | 0.650 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.032 | 3539.5 | 5477.5 | 1554.9 | -1.49 | 0.573 | 0.646 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.1 | 3497.0 | 5477.5 | 1554.9 | -1.0 | 0.562 | 0.638 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.32 | 3410.0 | 5477.5 | 1554.9 | -0.495 | 0.541 | 0.623 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 1.0 | 3340.0 | 5477.5 | 1554.9 | 0.0 | 0.523 | 0.610 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 3.2 | 3285.8 | 5477.5 | 1554.9 | 0.505 | 0.510 | 0.600 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.001 | 5293.5 | 5515.0 | 1554.9 | -3.0 | 0.956 | 0.960 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.0032 | 5319.0 | 5515.0 | 1554.9 | -2.49 | 0.961 | 0.964 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.01 | 5527.5 | 5515.0 | 1554.9 | -2.0 | 1.000 | 1.000 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.032 | 5304.8 | 5515.0 | 1554.9 | -1.49 | 0.958 | 0.962 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.1 | 5167.3 | 5515.0 | 1554.9 | -1.0 | 0.930 | 0.937 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 0.32 | 5000.0 | 5515.0 | 1554.9 | -0.495 | 0.895 | 0.907 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 1.0 | 4645.8 | 5515.0 | 1554.9 | 0.0 | 0.821 | 0.842 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | TGX221 | 1 | 72 | 3.2 | 4694.8 | 5515.0 | 1554.9 | 0.505 | 0.831 | 0.851 | 1.826 | BT549 TGX221 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 0.001 | 5013.8 | 5391.5 | 1554.9 | -3.0 | 0.921 | 0.930 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 0.0032 | 4538.0 | 5391.5 | 1554.9 | -2.49 | 0.817 | 0.842 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 0.01 | 3804.0 | 5391.5 | 1554.9 | -2.0 | 0.647 | 0.706 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 0.032 | 2665.0 | 5391.5 | 1554.9 | -1.49 | 0.350 | 0.494 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 0.1 | 2096.0 | 5391.5 | 1554.9 | -1.0 | 0.181 | 0.389 | 1.794 | BT549 Torin1 0 1 72 |