Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | Torin1 | 1 | 72 | 0.32 | 1841.8 | 5391.5 | 1554.9 | -0.495 | 0.099 | 0.342 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 1.0 | 1727.3 | 5391.5 | 1554.9 | 0.0 | 0.060 | 0.320 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin1 | 1 | 72 | 3.2 | 1780.5 | 5391.5 | 1554.9 | 0.505 | 0.078 | 0.330 | 1.794 | BT549 Torin1 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.001 | 4776.3 | 5306.0 | 1554.9 | -3.0 | 0.885 | 0.900 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.0032 | 4086.5 | 5306.0 | 1554.9 | -2.49 | 0.726 | 0.770 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.01 | 2879.8 | 5306.0 | 1554.9 | -2.0 | 0.416 | 0.543 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.032 | 2286.8 | 5306.0 | 1554.9 | -1.49 | 0.243 | 0.431 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.1 | 1857.3 | 5306.0 | 1554.9 | -1.0 | 0.106 | 0.350 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 0.32 | 1528.8 | 5306.0 | 1554.9 | -0.495 | -0.010 | 0.288 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 1.0 | 1265.8 | 5306.0 | 1554.9 | 0.0 | -0.110 | 0.239 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Torin2 | 1 | 72 | 3.2 | 1007.0 | 5306.0 | 1554.9 | 0.505 | -0.218 | 0.190 | 1.771 | BT549 Torin2 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.001 | 5342.5 | 5460.3 | 1554.9 | -3.0 | 0.976 | 0.978 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.0032 | 4985.0 | 5460.3 | 1554.9 | -2.49 | 0.902 | 0.913 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.01 | 5077.0 | 5460.3 | 1554.9 | -2.0 | 0.921 | 0.930 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.032 | 4930.8 | 5460.3 | 1554.9 | -1.49 | 0.891 | 0.903 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.1 | 4529.5 | 5460.3 | 1554.9 | -1.0 | 0.804 | 0.830 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 0.32 | 3881.8 | 5460.3 | 1554.9 | -0.495 | 0.657 | 0.711 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 1.0 | 3762.8 | 5460.3 | 1554.9 | 0.0 | 0.629 | 0.689 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | Trametinib | 1 | 72 | 3.2 | 3628.3 | 5460.3 | 1554.9 | 0.505 | 0.596 | 0.664 | 1.812 | BT549 Trametinib 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.001 | 5190.5 | 5366.3 | 1554.9 | -3.0 | 0.963 | 0.967 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.0032 | 4831.8 | 5366.3 | 1554.9 | -2.49 | 0.886 | 0.900 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.01 | 4307.5 | 5366.3 | 1554.9 | -2.0 | 0.769 | 0.803 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.032 | 3289.5 | 5366.3 | 1554.9 | -1.49 | 0.521 | 0.613 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.1 | 2314.8 | 5366.3 | 1554.9 | -1.0 | 0.249 | 0.431 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | WYE-125132 | 1 | 72 | 0.32 | 1923.3 | 5366.3 | 1554.9 | -0.495 | 0.126 | 0.358 | 1.787 | BT549 WYE125132 0 1 72 |