Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | KIN001-244 | 1 | 72 | 0.032 | 5462.8 | 5422.3 | 1554.9 | -1.49 | 1.010 | 1.010 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 0.1 | 5420.0 | 5422.3 | 1554.9 | -1.0 | 1.000 | 1.000 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 0.32 | 5191.0 | 5422.3 | 1554.9 | -0.495 | 0.952 | 0.957 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 1.0 | 5123.0 | 5422.3 | 1554.9 | 0.0 | 0.938 | 0.945 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 3.2 | 4812.3 | 5422.3 | 1554.9 | 0.505 | 0.872 | 0.888 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.001 | 5158.3 | 5457.0 | 1554.9 | -3.0 | 0.939 | 0.945 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.0032 | 5279.3 | 5457.0 | 1554.9 | -2.49 | 0.964 | 0.967 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.01 | 5011.5 | 5457.0 | 1554.9 | -2.0 | 0.908 | 0.918 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.032 | 4974.3 | 5457.0 | 1554.9 | -1.49 | 0.900 | 0.912 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.1 | 4760.3 | 5457.0 | 1554.9 | -1.0 | 0.855 | 0.872 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.32 | 4525.3 | 5457.0 | 1554.9 | -0.495 | 0.804 | 0.829 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 1.0 | 4905.0 | 5457.0 | 1554.9 | 0.0 | 0.886 | 0.899 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 3.2 | 6334.0 | 5457.0 | 1554.9 | 0.505 | 1.170 | 1.160 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.001 | 5272.0 | 5397.8 | 1554.9 | -3.0 | 0.974 | 0.977 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.0032 | 5385.3 | 5397.8 | 1554.9 | -2.49 | 0.997 | 0.998 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.01 | 5060.0 | 5397.8 | 1554.9 | -2.0 | 0.929 | 0.937 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.032 | 5002.0 | 5397.8 | 1554.9 | -1.49 | 0.917 | 0.927 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.1 | 4085.8 | 5397.8 | 1554.9 | -1.0 | 0.713 | 0.757 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 0.32 | 2729.8 | 5397.8 | 1554.9 | -0.495 | 0.368 | 0.506 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 1.0 | 2048.3 | 5397.8 | 1554.9 | 0.0 | 0.166 | 0.379 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PI103 | 1 | 72 | 3.2 | 1814.5 | 5397.8 | 1554.9 | 0.505 | 0.090 | 0.336 | 1.795 | BT549 PI103 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 0.001 | 5346.3 | 5328.0 | 1554.9 | -3.0 | 1.000 | 1.000 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 0.0032 | 5372.0 | 5328.0 | 1554.9 | -2.49 | 1.010 | 1.010 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 0.01 | 5272.8 | 5328.0 | 1554.9 | -2.0 | 0.988 | 0.990 | 1.777 | BT549 PIK93 0 1 72 |
| BT-549 | PIK-93 | 1 | 72 | 0.032 | 5369.3 | 5328.0 | 1554.9 | -1.49 | 1.010 | 1.010 | 1.777 | BT549 PIK93 0 1 72 |