Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | XL147 | 2 | 72 | 1.0 | 4855.5 | 4834.0 | 1249.6 | 0.0 | 1.000 | 1.000 | 1.952 | BT549 XL147 0 2 72 |
| BT-549 | XL147 | 2 | 72 | 3.2 | 4679.8 | 4834.0 | 1249.6 | 0.505 | 0.967 | 0.968 | 1.952 | BT549 XL147 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.001 | 4699.3 | 4867.8 | 1249.6 | -3.0 | 0.964 | 0.965 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.0032 | 4759.5 | 4867.8 | 1249.6 | -2.49 | 0.977 | 0.978 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.01 | 4539.3 | 4867.8 | 1249.6 | -2.0 | 0.930 | 0.933 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.032 | 4618.0 | 4867.8 | 1249.6 | -1.49 | 0.947 | 0.949 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.1 | 4170.3 | 4867.8 | 1249.6 | -1.0 | 0.848 | 0.857 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 0.32 | 3342.8 | 4867.8 | 1249.6 | -0.495 | 0.651 | 0.687 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 1.0 | 2352.8 | 4867.8 | 1249.6 | 0.0 | 0.381 | 0.483 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | ZSTK474 | 2 | 72 | 3.2 | 1627.3 | 4867.8 | 1249.6 | 0.505 | 0.144 | 0.334 | 1.962 | BT549 ZSTK474 0 2 72 |
| BT-549 | AS605240 | 3 | 72 | 0.001 | 4064.3 | 4082.5 | 1175.8 | -3.0 | 0.995 | 0.996 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.0032 | 3907.5 | 4082.5 | 1175.8 | -2.49 | 0.952 | 0.957 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.01 | 3935.3 | 4082.5 | 1175.8 | -2.0 | 0.960 | 0.964 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.032 | 3855.5 | 4082.5 | 1175.8 | -1.49 | 0.937 | 0.944 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.1 | 3917.5 | 4082.5 | 1175.8 | -1.0 | 0.955 | 0.960 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 0.32 | 3784.5 | 4082.5 | 1175.8 | -0.495 | 0.917 | 0.927 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 1.0 | 3682.3 | 4082.5 | 1175.8 | 0.0 | 0.888 | 0.902 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AS605240 | 3 | 72 | 3.2 | 3594.8 | 4082.5 | 1175.8 | 0.505 | 0.863 | 0.881 | 1.796 | BT549 AS605240 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.001 | 3961.8 | 3938.5 | 1175.8 | -3.0 | 1.010 | 1.010 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.0032 | 3898.5 | 3938.5 | 1175.8 | -2.49 | 0.988 | 0.990 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.01 | 3828.0 | 3938.5 | 1175.8 | -2.0 | 0.968 | 0.972 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.032 | 3826.0 | 3938.5 | 1175.8 | -1.49 | 0.967 | 0.971 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.1 | 3789.3 | 3938.5 | 1175.8 | -1.0 | 0.956 | 0.962 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 0.32 | 3499.3 | 3938.5 | 1175.8 | -0.495 | 0.869 | 0.888 | 1.744 | BT549 AZD6482 0 3 72 |
| BT-549 | AZD-6482 | 3 | 72 | 1.0 | 3139.3 | 3938.5 | 1175.8 | 0.0 | 0.756 | 0.797 | 1.744 | BT549 AZD6482 0 3 72 |