Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Trametinib | 3 | 72 | 1.0 | 2177.5 | 3410.0 | 586.9 | 0.0 | 0.676 | 0.639 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 3.2 | 2061.3 | 3410.0 | 586.9 | 0.505 | 0.640 | 0.604 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.001 | 3058.5 | 3344.0 | 586.9 | -3.0 | 0.930 | 0.915 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.0032 | 2937.3 | 3344.0 | 586.9 | -2.49 | 0.899 | 0.878 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.01 | 2864.0 | 3344.0 | 586.9 | -2.0 | 0.880 | 0.856 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.032 | 2304.3 | 3344.0 | 586.9 | -1.49 | 0.724 | 0.689 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.1 | 1137.8 | 3344.0 | 586.9 | -1.0 | 0.302 | 0.340 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.32 | 917.3 | 3344.0 | 586.9 | -0.495 | 0.195 | 0.274 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 1.0 | 807.3 | 3344.0 | 586.9 | 0.0 | 0.135 | 0.241 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 3.2 | 735.8 | 3344.0 | 586.9 | 0.505 | 0.094 | 0.220 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.001 | 2958.8 | 3677.3 | 586.9 | -3.0 | 0.842 | 0.805 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.0032 | 3135.3 | 3677.3 | 586.9 | -2.49 | 0.883 | 0.853 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.01 | 3287.5 | 3677.3 | 586.9 | -2.0 | 0.917 | 0.894 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.032 | 3323.3 | 3677.3 | 586.9 | -1.49 | 0.925 | 0.904 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.1 | 3310.0 | 3677.3 | 586.9 | -1.0 | 0.922 | 0.900 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 0.32 | 3482.5 | 3677.3 | 586.9 | -0.495 | 0.959 | 0.947 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 1.0 | 3116.3 | 3677.3 | 586.9 | 0.0 | 0.879 | 0.847 | 2.647 | BT20 XL147 0 3 |
| BT-20 | XL147 | 3 | 72 | 3.2 | 2603.5 | 3677.3 | 586.9 | 0.505 | 0.755 | 0.708 | 2.647 | BT20 XL147 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.001 | 3277.0 | 3579.5 | 586.9 | -3.0 | 0.933 | 0.915 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.0032 | 3250.5 | 3579.5 | 586.9 | -2.49 | 0.927 | 0.908 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.01 | 3301.0 | 3579.5 | 586.9 | -2.0 | 0.939 | 0.922 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.032 | 3138.0 | 3579.5 | 586.9 | -1.49 | 0.902 | 0.877 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.1 | 2816.5 | 3579.5 | 586.9 | -1.0 | 0.824 | 0.787 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.32 | 2178.5 | 3579.5 | 586.9 | -0.495 | 0.653 | 0.609 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 1.0 | 982.5 | 3579.5 | 586.9 | 0.0 | 0.218 | 0.274 | 2.609 | BT20 ZSTK474 0 3 |