Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TGX221 | 3 | 72 | 0.32 | 3331.5 | 3248.8 | 586.9 | -0.495 | 1.020 | 1.030 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | TGX221 | 3 | 72 | 1.0 | 3366.0 | 3248.8 | 586.9 | 0.0 | 1.030 | 1.040 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | TGX221 | 3 | 72 | 3.2 | 3280.0 | 3248.8 | 586.9 | 0.505 | 1.010 | 1.010 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.001 | 3206.0 | 3483.3 | 586.9 | -3.0 | 0.936 | 0.920 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.0032 | 2865.5 | 3483.3 | 586.9 | -2.49 | 0.854 | 0.823 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.01 | 2251.5 | 3483.3 | 586.9 | -2.0 | 0.688 | 0.646 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.032 | 1460.5 | 3483.3 | 586.9 | -1.49 | 0.426 | 0.419 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.1 | 1001.5 | 3483.3 | 586.9 | -1.0 | 0.231 | 0.288 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.32 | 895.0 | 3483.3 | 586.9 | -0.495 | 0.178 | 0.257 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 1.0 | 814.0 | 3483.3 | 586.9 | 0.0 | 0.136 | 0.234 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin1 | 3 | 72 | 3.2 | 640.0 | 3483.3 | 586.9 | 0.505 | 0.034 | 0.184 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.001 | 2975.8 | 3225.3 | 586.9 | -3.0 | 0.936 | 0.923 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.0032 | 2346.0 | 3225.3 | 586.9 | -2.49 | 0.757 | 0.727 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.01 | 1818.3 | 3225.3 | 586.9 | -2.0 | 0.584 | 0.564 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.032 | 1034.3 | 3225.3 | 586.9 | -1.49 | 0.259 | 0.321 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.1 | 823.5 | 3225.3 | 586.9 | -1.0 | 0.148 | 0.255 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 0.32 | 707.8 | 3225.3 | 586.9 | -0.495 | 0.079 | 0.219 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 1.0 | 307.3 | 3225.3 | 586.9 | 0.0 | -0.231 | 0.095 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Torin2 | 3 | 72 | 3.2 | 47.8 | 3225.3 | 586.9 | 0.505 | -0.640 | 0.015 | 2.458 | BT20 Torin2 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.001 | 3203.3 | 3410.0 | 586.9 | -3.0 | 0.951 | 0.939 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.0032 | 2978.0 | 3410.0 | 586.9 | -2.49 | 0.896 | 0.873 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.01 | 2753.3 | 3410.0 | 586.9 | -2.0 | 0.838 | 0.807 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.032 | 2817.0 | 3410.0 | 586.9 | -1.49 | 0.855 | 0.826 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.1 | 2547.3 | 3410.0 | 586.9 | -1.0 | 0.783 | 0.747 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.32 | 2256.3 | 3410.0 | 586.9 | -0.495 | 0.700 | 0.662 | 2.539 | BT20 Trametinib 0 3 |