Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 MK2206 2 72
0.1
 3009.3 3399.5 1018.6
-1.0
 0.865 0.885 1.739
BT20 MK2206 0 2
BT-20 MK2206 2 72
0.32
 2588.8 3399.5 1018.6
-0.495
 0.710 0.762 1.739
BT20 MK2206 0 2
BT-20 MK2206 2 72
1.0
 1954.3 3399.5 1018.6
0.0
 0.455 0.575 1.739
BT20 MK2206 0 2
BT-20 MK2206 2 72
3.2
 1182.5 3399.5 1018.6
0.505
 0.090 0.348 1.739
BT20 MK2206 0 2
BT-20 PI103 2 72
0.001
 2853.5 3367.0 1018.6
-3.0
 0.817 0.847 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
0.0032
 3161.0 3367.0 1018.6
-2.49
 0.928 0.939 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
0.01
 3324.3 3367.0 1018.6
-2.0
 0.985 0.987 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
0.032
 3214.0 3367.0 1018.6
-1.49
 0.947 0.955 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
0.1
 2964.3 3367.0 1018.6
-1.0
 0.858 0.880 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
0.32
 1644.5 3367.0 1018.6
-0.495
 0.320 0.488 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
1.0
 929.3 3367.0 1018.6
0.0
 -0.052 0.276 1.725
BT20 PI103 0 2
BT-20 PI103 2 72
3.2
 678.8 3367.0 1018.6
0.505
 -0.210 0.202 1.725
BT20 PI103 0 2
BT-20 PIK-93 2 72
0.001
 2970.8 3542.3 1018.6
-3.0
 0.814 0.839 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
0.0032
 3026.5 3542.3 1018.6
-2.49
 0.832 0.854 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
0.01
 3034.8 3542.3 1018.6
-2.0
 0.835 0.857 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
0.032
 2813.3 3542.3 1018.6
-1.49
 0.759 0.794 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
0.1
 2942.5 3542.3 1018.6
-1.0
 0.804 0.831 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
0.32
 2764.8 3542.3 1018.6
-0.495
 0.743 0.781 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
1.0
 2226.5 3542.3 1018.6
0.0
 0.545 0.629 1.798
BT20 PIK93 0 2
BT-20 PIK-93 2 72
3.2
 1319.8 3542.3 1018.6
0.505
 0.155 0.373 1.798
BT20 PIK93 0 2
BT-20 Sirolimus 2 72
0.001
 1740.0 3606.8 1018.6
-3.0
 0.341 0.482 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
0.0032
 1644.3 3606.8 1018.6
-2.49
 0.300 0.456 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
0.01
 1703.3 3606.8 1018.6
-2.0
 0.326 0.472 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
0.032
 1569.0 3606.8 1018.6
-1.49
 0.267 0.435 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
0.1
 1473.3 3606.8 1018.6
-1.0
 0.224 0.408 1.824
BT20 Rapamycin 0 2