Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin2 | 2 | 72 | 1.0 | 466.8 | 3386.5 | 1018.6 | 0.0 | -0.362 | 0.138 | 1.733 | BT20 Torin2 0 2 |
| BT-20 | Torin2 | 2 | 72 | 3.2 | 85.5 | 3386.5 | 1018.6 | 0.505 | -0.761 | 0.025 | 1.733 | BT20 Torin2 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.001 | 2987.3 | 3363.5 | 1018.6 | -3.0 | 0.867 | 0.888 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.0032 | 3326.3 | 3363.5 | 1018.6 | -2.49 | 0.987 | 0.989 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.01 | 2910.5 | 3363.5 | 1018.6 | -2.0 | 0.839 | 0.865 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.032 | 2797.0 | 3363.5 | 1018.6 | -1.49 | 0.797 | 0.832 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.1 | 2527.0 | 3363.5 | 1018.6 | -1.0 | 0.694 | 0.751 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 0.32 | 2314.0 | 3363.5 | 1018.6 | -0.495 | 0.610 | 0.688 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 1.0 | 1967.5 | 3363.5 | 1018.6 | 0.0 | 0.465 | 0.585 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Trametinib | 2 | 72 | 3.2 | 1608.0 | 3363.5 | 1018.6 | 0.505 | 0.303 | 0.478 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.001 | 2942.5 | 3613.5 | 1018.6 | -3.0 | 0.787 | 0.814 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.0032 | 3226.8 | 3613.5 | 1018.6 | -2.49 | 0.880 | 0.893 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.01 | 2746.5 | 3613.5 | 1018.6 | -2.0 | 0.721 | 0.760 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.032 | 1915.3 | 3613.5 | 1018.6 | -1.49 | 0.413 | 0.530 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.1 | 1155.5 | 3613.5 | 1018.6 | -1.0 | 0.072 | 0.320 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.32 | 887.5 | 3613.5 | 1018.6 | -0.495 | -0.073 | 0.246 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 1.0 | 847.0 | 3613.5 | 1018.6 | 0.0 | -0.096 | 0.234 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 3.2 | 831.0 | 3613.5 | 1018.6 | 0.505 | -0.105 | 0.230 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.001 | 2825.8 | 3509.0 | 1018.6 | -3.0 | 0.771 | 0.805 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.0032 | 3241.3 | 3509.0 | 1018.6 | -2.49 | 0.913 | 0.924 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.01 | 3465.5 | 3509.0 | 1018.6 | -2.0 | 0.986 | 0.988 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.032 | 3497.3 | 3509.0 | 1018.6 | -1.49 | 0.996 | 0.997 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.1 | 3373.3 | 3509.0 | 1018.6 | -1.0 | 0.956 | 0.961 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 0.32 | 3297.8 | 3509.0 | 1018.6 | -0.495 | 0.932 | 0.940 | 1.784 | BT20 XL147 0 2 |
| BT-20 | XL147 | 2 | 72 | 1.0 | 3330.0 | 3509.0 | 1018.6 | 0.0 | 0.942 | 0.949 | 1.784 | BT20 XL147 0 2 |