Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | XL147 | 2 | 72 | 3.2 | 2791.8 | 3509.0 | 1018.6 | 0.505 | 0.759 | 0.796 | 1.784 | BT20 XL147 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.001 | 3212.8 | 3516.3 | 1018.6 | -3.0 | 0.902 | 0.914 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.0032 | 3396.8 | 3516.3 | 1018.6 | -2.49 | 0.962 | 0.966 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.01 | 3448.5 | 3516.3 | 1018.6 | -2.0 | 0.978 | 0.981 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.032 | 3425.3 | 3516.3 | 1018.6 | -1.49 | 0.971 | 0.974 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.1 | 3083.0 | 3516.3 | 1018.6 | -1.0 | 0.858 | 0.877 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 0.32 | 1947.3 | 3516.3 | 1018.6 | -0.495 | 0.437 | 0.554 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 1.0 | 1046.8 | 3516.3 | 1018.6 | 0.0 | 0.015 | 0.298 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | ZSTK474 | 2 | 72 | 3.2 | 699.5 | 3516.3 | 1018.6 | 0.505 | -0.190 | 0.199 | 1.787 | BT20 ZSTK474 0 2 |
| BT-20 | AS605240 | 3 | 72 | 0.001 | 3319.5 | 3575.0 | 586.9 | -3.0 | 0.944 | 0.929 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.0032 | 3254.5 | 3575.0 | 586.9 | -2.49 | 0.929 | 0.910 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.01 | 3575.3 | 3575.0 | 586.9 | -2.0 | 1.000 | 1.000 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.032 | 3388.8 | 3575.0 | 586.9 | -1.49 | 0.959 | 0.948 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.1 | 3148.5 | 3575.0 | 586.9 | -1.0 | 0.905 | 0.881 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.32 | 3050.3 | 3575.0 | 586.9 | -0.495 | 0.882 | 0.853 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 1.0 | 2935.8 | 3575.0 | 586.9 | 0.0 | 0.854 | 0.821 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 3.2 | 2896.3 | 3575.0 | 586.9 | 0.505 | 0.845 | 0.810 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.001 | 3256.8 | 3560.8 | 586.9 | -3.0 | 0.933 | 0.915 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.0032 | 3136.8 | 3560.8 | 586.9 | -2.49 | 0.905 | 0.881 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.01 | 3282.5 | 3560.8 | 586.9 | -2.0 | 0.938 | 0.922 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.032 | 3397.0 | 3560.8 | 586.9 | -1.49 | 0.964 | 0.954 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.1 | 3118.3 | 3560.8 | 586.9 | -1.0 | 0.901 | 0.876 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.32 | 2758.0 | 3560.8 | 586.9 | -0.495 | 0.813 | 0.775 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 1.0 | 2162.8 | 3560.8 | 586.9 | 0.0 | 0.651 | 0.607 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 3.2 | 1162.3 | 3560.8 | 586.9 | 0.505 | 0.300 | 0.326 | 2.601 | BT20 AZD6482 0 3 |