Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | KIN001-244 | 1 | 72 | 0.1 | 6567.5 | 6295.0 | 1443.3 | -1.0 | 1.040 | 1.040 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.32 | 6065.5 | 6295.0 | 1443.3 | -0.495 | 0.965 | 0.964 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 1.0 | 5975.3 | 6295.0 | 1443.3 | 0.0 | 0.952 | 0.949 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 3.2 | 5716.5 | 6295.0 | 1443.3 | 0.505 | 0.911 | 0.908 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.001 | 5632.5 | 6138.5 | 1443.3 | -3.0 | 0.919 | 0.918 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.0032 | 5903.0 | 6138.5 | 1443.3 | -2.49 | 0.963 | 0.962 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.01 | 6080.5 | 6138.5 | 1443.3 | -2.0 | 0.991 | 0.991 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.032 | 5766.3 | 6138.5 | 1443.3 | -1.49 | 0.941 | 0.939 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.1 | 5642.5 | 6138.5 | 1443.3 | -1.0 | 0.921 | 0.919 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.32 | 5295.3 | 6138.5 | 1443.3 | -0.495 | 0.863 | 0.863 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 1.0 | 4545.8 | 6138.5 | 1443.3 | 0.0 | 0.732 | 0.741 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | MK2206 | 1 | 72 | 3.2 | 5077.7 | 6138.5 | 1443.3 | 0.505 | 0.826 | 0.827 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.001 | 5370.5 | 5476.0 | 1443.3 | -3.0 | 0.980 | 0.981 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.0032 | 5811.0 | 5476.0 | 1443.3 | -2.49 | 1.060 | 1.060 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.01 | 6019.5 | 5476.0 | 1443.3 | -2.0 | 1.100 | 1.100 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.032 | 6102.5 | 5476.0 | 1443.3 | -1.49 | 1.120 | 1.110 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.1 | 5635.0 | 5476.0 | 1443.3 | -1.0 | 1.030 | 1.030 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.32 | 4753.0 | 5476.0 | 1443.3 | -0.495 | 0.858 | 0.868 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 1.0 | 2166.0 | 5476.0 | 1443.3 | 0.0 | 0.235 | 0.396 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 3.2 | 1411.8 | 5476.0 | 1443.3 | 0.505 | -0.011 | 0.258 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.001 | 5862.8 | 5875.8 | 1443.3 | -3.0 | 0.998 | 0.998 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.0032 | 5799.0 | 5875.8 | 1443.3 | -2.49 | 0.987 | 0.987 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.01 | 5717.0 | 5875.8 | 1443.3 | -2.0 | 0.973 | 0.973 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.032 | 5933.3 | 5875.8 | 1443.3 | -1.49 | 1.010 | 1.010 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.1 | 5635.8 | 5875.8 | 1443.3 | -1.0 | 0.959 | 0.959 | 2.025 | BT20 PIK93 0 1 |