Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
BT-20 Sirolimus 2 72
0.32
 1657.0 3606.8 1018.6
-0.495
 0.306 0.459 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
1.0
 1444.8 3606.8 1018.6
0.0
 0.211 0.401 1.824
BT20 Rapamycin 0 2
BT-20 Sirolimus 2 72
3.2
 1394.3 3606.8 1018.6
0.505
 0.188 0.387 1.824
BT20 Rapamycin 0 2
BT-20 TGX221 2 72
0.001
 2691.8 3211.0 1018.6
-3.0
 0.798 0.838 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
0.0032
 2876.0 3211.0 1018.6
-2.49
 0.871 0.896 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
0.01
 3013.8 3211.0 1018.6
-2.0
 0.925 0.939 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
0.032
 3177.3 3211.0 1018.6
-1.49
 0.987 0.990 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
0.1
 3128.0 3211.0 1018.6
-1.0
 0.969 0.974 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
0.32
 3127.5 3211.0 1018.6
-0.495
 0.968 0.974 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
1.0
 3337.0 3211.0 1018.6
0.0
 1.050 1.040 1.656
BT20 TGX221 0 2
BT-20 TGX221 2 72
3.2
 3212.3 3211.0 1018.6
0.505
 1.000 1.000 1.656
BT20 TGX221 0 2
BT-20 Torin1 2 72
0.001
 3090.8 3530.0 1018.6
-3.0
 0.857 0.876 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
0.0032
 2586.8 3530.0 1018.6
-2.49
 0.682 0.733 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
0.01
 2110.5 3530.0 1018.6
-2.0
 0.501 0.598 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
0.032
 1205.8 3530.0 1018.6
-1.49
 0.099 0.342 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
0.1
 858.8 3530.0 1018.6
-1.0
 -0.091 0.243 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
0.32
 815.5 3530.0 1018.6
-0.495
 -0.117 0.231 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
1.0
 889.5 3530.0 1018.6
0.0
 -0.073 0.252 1.793
BT20 Torin1 0 2
BT-20 Torin1 2 72
3.2
 757.8 3530.0 1018.6
0.505
 -0.152 0.215 1.793
BT20 Torin1 0 2
BT-20 Torin2 2 72
0.001
 2643.0 3386.5 1018.6
-3.0
 0.733 0.780 1.733
BT20 Torin2 0 2
BT-20 Torin2 2 72
0.0032
 2073.0 3386.5 1018.6
-2.49
 0.507 0.612 1.733
BT20 Torin2 0 2
BT-20 Torin2 2 72
0.01
 1662.5 3386.5 1018.6
-2.0
 0.327 0.491 1.733
BT20 Torin2 0 2
BT-20 Torin2 2 72
0.032
 911.5 3386.5 1018.6
-1.49
 -0.062 0.269 1.733
BT20 Torin2 0 2
BT-20 Torin2 2 72
0.1
 773.3 3386.5 1018.6
-1.0
 -0.147 0.228 1.733
BT20 Torin2 0 2
BT-20 Torin2 2 72
0.32
 701.3 3386.5 1018.6
-0.495
 -0.194 0.207 1.733
BT20 Torin2 0 2