Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| HCC1395 | RO-3306 | 0.479643325 | -0.1494 | 0.4249 | 6.7176 | -1.0000 | 0.4162 | 0.8546 | 3.39e-11 |
| MDA-MB-453 | RO-3306 | 5.832801693 | 0.0432 | 0.0980 | 10.4904 | -1.0000 | 1.8717 | 0.8565 | 2.89e-11 |
| CAL-120 | LY3023414 | 0.001726062 | 0.0262 | 0.6878 | 0.0014 | 0.0252 | 0.2428 | 0.8575 | 2.65e-11 |
| MDA-MB-453 | AZD5363 | 1.537709354 | 0.1686 | 0.2591 | 1.2036 | 0.0741 | 0.6549 | 0.8588 | 2.35e-11 |
| HCC1428 | THZ1 | 0.011292388 | -0.8773 | 0.6550 | 0.0212 | -0.7576 | 1.4635 | 0.8598 | 2.16e-11 |
| CAL-51 | THZ531 | 1.43076633 | 0.5402 | 0.0683 | 0.9405 | 0.1606 | 0.9231 | 0.8600 | 2.12e-11 |
| T47D | Ulixertinib | 3.528421043 | 0.1952 | 0.2003 | 28.8265 | -1.0000 | 0.5230 | 0.8600 | 2.12e-11 |
| BT-20 | AZD5363 | 1.72900360981 | 0.1717 | 0.3013 | 86.6237 | -1.0000 | 0.2807 | 0.8604 | 2.05393480002e-11 |
| HCC1937 | MK 1775 | 0.008394634 | -0.1880 | 0.6919 | 0.0152 | -0.1214 | 0.3668 | 0.8610 | 1.94e-11 |
| BT-20 | Ribociclib | 0.364051568488 | 0.0541 | 0.4406 | 65.2706 | -1.0000 | 0.2117 | 0.8623 | 1.72427627732e-11 |
| MCF7 | Ulixertinib | 3.786667089 | 0.3222 | 0.1986 | 9.6095 | -0.2846 | 0.4838 | 0.8626 | 1.69e-11 |
| SUM149PT | Ribociclib | 229.6984296 | 0.5649 | 0.1855 | 1.4808 | 0.4031 | 0.3252 | 0.8653 | 1.31e-11 |
| BT-20 | AZD2014 | 0.129099948542 | 0.1187 | 0.4911 | 0.6794 | -0.2850 | 0.2716 | 0.8667 | 1.14693810005e-11 |
| HCC1143 | LY3023414 | 0.280841078 | -0.2472 | 0.4301 | 9.5524 | -1.0000 | 0.3115 | 0.8676 | 1.05e-11 |
| MDA-MB-231 | LY3023414 | 0.024794302589 | -0.1925 | 0.6229 | 9.4401 | -0.9822 | 0.1829 | 0.8678 | 1.03200781254e-11 |
| AU565 | MK 1775 | 0.223405816 | -0.4543 | 0.4894 | 3.6482 | -1.0000 | 0.3933 | 0.8692 | 9.09e-12 |
| SUM159PT | THZ531 | 1.158729591 | 0.6103 | 0.0475 | 1.7617 | -1.0000 | 2.6222 | 0.8700 | 8.37e-12 |
| MDA-MB-157 | LY3023414 | 0.120671918 | -0.4605 | 0.5635 | 2.6226 | -1.0000 | 0.3568 | 0.8702 | 8.21e-12 |
| AU565 | LY3023414 | 0.003983539 | -0.4704 | 0.7921 | 0.8999 | -1.0000 | 0.2027 | 0.8707 | 7.87e-12 |
| HCC70 | AZD5363 | 0.0251705169742 | -0.2793 | 0.6653 | 0.5821 | -0.6722 | 0.2713 | 0.8708 | 7.80986386673e-12 |
| MDA-MB-468 | BMS-265246 | 0.129448207 | -0.1039 | 0.5150 | 7.7796 | -1.0000 | 0.2682 | 0.8711 | 7.57e-12 |
| HME1 | AZD6738 | 5.825895792 | 0.2920 | 0.0055 | 4.9604 | 0.2763 | 5.0000 | 0.8741 | 5.61e-12 |
| MCF 10A | Ribociclib | 11.7857143478 | 0.4369 | 0.2382 | 1000.0000 | -0.8407 | 0.2221 | 0.8769 | 4.26025881239e-12 |
| SUM1315MO2 | AZD6738 | 4.435414924 | -0.1764 | 0.0538 | 8.3060 | -1.0000 | 1.7512 | 0.8774 | 4.02e-12 |