Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)

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Cell Small Molecule GR50 GRmax GR_AOC GEC50 GRinf GR Hill Coefficient GR r2 pval_GR
HCC38 GSK2334470
362.2276812
 0.7326 0.0411 1000.0000 -0.2309 0.3738 0.3294
0.006774661
CAL-85-1 Ulixertinib
3.83746694
 0.2311 0.2960 72.1557 -1.0000 0.3744 0.3008
0.011412092
Hs 578T AZD2014
0.068067431
 0.2555 0.5090 0.0201 0.1834 0.3744 0.9704
1.11e-16
SUM1315MO2 SHP099
22.32790504
 0.4783 0.1197 419.3194 -1.0000 0.3746 0.3197
0.008107411
SUM149PT BMS-265246
0.016950371
 0.0738 0.6317 0.0171 -0.0015 0.3767 0.9526
1.11e-16
MDA-MB-453 GSK2334470
2.045052119
 0.1203 0.2628 36.8285 -1.0000 0.3800 0.7865
4.15e-09
Hs 578T Ulixertinib
1.12758771
 0.2421 0.3284 1.7251 -0.0883 0.3825 0.9567
1.11e-16
HCC1419 GSK2334470
7.272032069
 0.4604 0.2878 0.7439 0.2916 0.3838 0.5825
1.81e-05
HCC1954 AZD5363
2.96992805185
 0.2599 0.2385 51.5317 -1.0000 0.3850 0.8789
3.45068418284e-12
HCC38 Senexin B
15.63810324
 0.5236 0.1411 269.9088 -0.9985 0.3853 0.5885
1.51e-05
HCC1937 AZD5363
12.85319785
 0.4773 0.3596 0.0112 0.4671 0.3863 0.5345
7.07e-05
CAL-85-1 MK 1775
0.182874423
 -0.5298 0.5409 3.0854 -1.0000 0.3888 0.7205
1.2e-07
Hs 578T MK 1775
0.014507078
 -0.3462 0.7648 0.0762 -0.4564 0.3909 0.9740
1.11e-16
HCC1143 BMS-265246
0.001767259
 -0.0571 0.8227 0.0030 -0.1138 0.3912 0.9074
1.21e-13
CAMA-1 Ulixertinib
2.566161953
 0.1288 0.2586 42.4009 -1.0000 0.3917 0.5616
3.34e-05
AU565 MK 1775
0.223405816
 -0.4543 0.4894 3.6482 -1.0000 0.3933 0.8692
9.09e-12
MCF7 Ribociclib
0.189284804
 0.2285 0.4067 0.0345 0.2453 0.3959 0.8429
8.95e-11
CAL-51 MK 1775
0.310910353
 -0.1886 0.4395 4.9452 -1.0000 0.3971 0.9792
1.11e-16
HCC1806 Senexin B
inf
 0.8083 0.1042 0.1453 0.7979 0.4002 0.4857
0.000245355132328
MDA-MB-436 Ulixertinib
34.76507133
 0.5719 0.1213 534.6670 -1.0000 0.4020 0.5984
1.11e-05
HCC38 BMS-265246
0.00394749
 -0.0214 0.7767 0.0054 -0.0686 0.4043 0.9575
1.11e-16
HCC1419 AZD2014
0.000451019
 -0.1328 0.9581 0.0009 -0.1553 0.4080 0.8343
1.75e-10
HCC1937 BMS-265246
0.000340758
 -0.0634 0.9143 0.0005 -0.0734 0.4108 0.8462
6.89e-11
HCC1395 BMS-265246
0.005815242
 -0.2349 0.7953 0.0151 -0.2416 0.4121 0.9312
3e-15
HCC1395 RO-3306
0.479643325
 -0.1494 0.4249 6.7176 -1.0000 0.4162 0.8546
3.39e-11