Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | AZD5363 | inf | 0.2770 | 0.1987 | 0.0000 | 0.8552 | 0.0100 | 0.0000 | 0.179970694 |
| CAL-85-1 | AZD6738 | 6.237645512 | 0.1470 | 0.1766 | 11.7933 | -1.0000 | 1.7249 | 0.5594 | 3.56e-05 |
| CAL-85-1 | BMS-265246 | 0.006551436 | -0.0684 | 0.7136 | 8.4904 | -1.0000 | 0.1533 | 0.7672 | 1.22e-08 |
| CAL-85-1 | Ulixertinib | 3.83746694 | 0.2311 | 0.2960 | 72.1557 | -1.0000 | 0.3744 | 0.3008 | 0.011412092 |
| CAL-85-1 | Alvocidib | 0.160024022 | -0.3171 | 0.3835 | 0.1856 | -0.2356 | 2.6082 | 0.7113 | 1.8e-07 |
| CAL-85-1 | GSK2334470 | inf | 0.1906 | 0.2483 | 0.0000 | 0.7764 | 0.0100 | 0.0000 | 0.11208861 |
| CAL-85-1 | Ribociclib | inf | 0.9479 | 0.1502 | 0.0000 | 0.8929 | 0.0100 | 0.0000 | 1.0 |
| CAL-85-1 | LY3023414 | 0.000296659 | -0.1414 | 0.7983 | 0.0033 | -0.2397 | 0.1626 | 0.7206 | 1.2e-07 |
| CAL-85-1 | RO-3306 | 6.045627864 | -0.3140 | 0.2213 | 9.4578 | -1.0000 | 2.4550 | 0.5125 | 0.000125886 |
| CAL-85-1 | Rucaparib | 15.9069887 | 0.3496 | 0.2765 | 1000.0000 | -0.6758 | 0.2065 | 0.3127 | 0.009204617 |
| CAL-85-1 | Senexin B | inf | 0.7288 | 0.3316 | 0.0000 | 0.7468 | 0.0100 | 0.0000 | 0.98409231 |
| CAL-85-1 | SHP099 | inf | 0.5820 | 0.2604 | 0.0000 | 0.8282 | 0.0100 | 0.0000 | 1.0 |
| CAL-85-1 | THZ1 | 0.007789492 | -0.5032 | 0.6841 | 0.0452 | -0.7693 | 0.5298 | 0.8779 | 3.85e-12 |
| CAL-85-1 | THZ531 | 0.06303794 | -0.2628 | 0.4242 | 0.3186 | -0.8133 | 0.5961 | 0.6795 | 6.65e-07 |
| CAMA-1 | MK 1775 | 5.412146559 | -0.2519 | 0.0565 | 8.5802 | -1.0000 | 2.3841 | 0.7821 | 5.36e-09 |
| CAMA-1 | AZD2014 | 4.02e-06 | -0.0824 | 0.8730 | 0.0055 | -0.5291 | 0.1000 | 0.5846 | 1.7e-05 |
| CAMA-1 | AZD5363 | 0.048497519 | -0.1534 | 0.5494 | 10.8262 | -1.0000 | 0.2031 | 0.8383 | 1.28e-10 |
| CAMA-1 | AZD6738 | 8.908669378 | 0.2804 | -0.0237 | 11.1124 | -1.0000 | 4.9704 | 0.6787 | 6.86e-07 |
| CAMA-1 | BMS-265246 | 0.000235768 | -0.0623 | 0.8248 | 0.0086 | -0.4066 | 0.1654 | 0.7534 | 2.51e-08 |
| CAMA-1 | Ulixertinib | 2.566161953 | 0.1288 | 0.2586 | 42.4009 | -1.0000 | 0.3917 | 0.5616 | 3.34e-05 |
| CAMA-1 | Alvocidib | 0.174755194 | -0.1534 | 0.2533 | 0.7555 | -1.0000 | 0.7504 | 0.7392 | 5.05e-08 |
| CAMA-1 | GSK2334470 | inf | 0.6437 | -0.0125 | 0.0000 | 0.9959 | 0.0100 | 0.0000 | 0.05607765 |
| CAMA-1 | Ribociclib | 0.009012358 | 0.1601 | 0.6510 | 0.0058 | 0.0871 | 0.4330 | 0.8208 | 4.65e-10 |
| CAMA-1 | LY3023414 | 4.27e-05 | -0.5001 | 0.9375 | 0.0004 | -0.2985 | 0.2143 | 0.5057 | 0.00014946 |
| CAMA-1 | RO-3306 | 5.997561215 | -0.0078 | 0.0792 | 9.5303 | -0.8318 | 2.1153 | 0.7822 | 5.32e-09 |