Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | Rucaparib | inf | 0.8528 | 0.1254 | 0.0108 | 0.8301 | 5.0000 | 0.2588 | 0.023653062 |
| CAMA-1 | Senexin B | 1.06482186 | 0.2022 | 0.3355 | 175.6924 | -1.0000 | 0.2152 | 0.5567 | 3.84e-05 |
| CAMA-1 | SHP099 | inf | 0.6544 | 0.0867 | 0.0000 | 0.9242 | 0.0100 | 0.0000 | 0.798838019 |
| CAMA-1 | THZ1 | 0.032222346 | -0.5114 | 0.4685 | 0.2234 | -1.0000 | 0.5674 | 0.9266 | 6.55e-15 |
| CAMA-1 | THZ531 | 0.137279719 | -0.3792 | 0.2548 | 0.1832 | -0.4135 | 2.0894 | 0.8990 | 3.6e-13 |
| HCC1143 | MK 1775 | 0.667235616 | -0.4310 | 0.3475 | 4.0400 | -1.0000 | 0.6101 | 0.9306 | 3.33e-15 |
| HCC1143 | AZD2014 | 0.421624866 | 0.1334 | 0.3982 | 59.1681 | -1.0000 | 0.2222 | 0.9449 | 2.22e-16 |
| HCC1143 | AZD5363 | 904.4573761 | 0.7083 | 0.0803 | 1000.0000 | -0.0144 | 0.2833 | 0.5816 | 1.86e-05 |
| HCC1143 | AZD6738 | 5.179476247 | -0.0433 | 0.0238 | 8.9090 | -0.8835 | 1.8765 | 0.9171 | 3.01e-14 |
| HCC1143 | BMS-265246 | 0.001767259 | -0.0571 | 0.8227 | 0.0030 | -0.1138 | 0.3912 | 0.9074 | 1.21e-13 |
| HCC1143 | Ulixertinib | 1.718095034 | 0.0344 | 0.2458 | 19.1869 | -1.0000 | 0.4553 | 0.8884 | 1.25e-12 |
| HCC1143 | Alvocidib | 0.171201738 | -0.3370 | 0.2245 | 0.2832 | -0.5220 | 1.4205 | 0.9893 | 1.11e-16 |
| HCC1143 | GSK2334470 | 438.6004495 | 0.6788 | 0.0824 | 1000.0000 | -0.1385 | 0.2967 | 0.5027 | 0.000161396 |
| HCC1143 | Ribociclib | 3.643695147 | 0.3009 | 0.2535 | 264.9902 | -1.0000 | 0.2563 | 0.8300 | 2.41e-10 |
| HCC1143 | LY3023414 | 0.280841078 | -0.2472 | 0.4301 | 9.5524 | -1.0000 | 0.3115 | 0.8676 | 1.05e-11 |
| HCC1143 | RO-3306 | 1.73126532 | -0.1079 | 0.2418 | 3.9460 | -0.5002 | 0.8416 | 0.9451 | 2.22e-16 |
| HCC1143 | Rucaparib | 212371.6019 | 0.7856 | 0.0507 | 630.9562 | 0.3840 | 0.2511 | 0.2497 | 0.027576264 |
| HCC1143 | Senexin B | 16.15394735 | 0.4142 | 0.1852 | 1000.0000 | -0.7697 | 0.2259 | 0.6559 | 1.62e-06 |
| HCC1143 | SHP099 | 1449.842823 | 0.7869 | 0.0529 | 1000.0000 | 0.0556 | 0.3172 | 0.3933 | 0.001935462 |
| HCC1143 | THZ1 | 0.026504565 | -0.2975 | 0.4699 | 0.0315 | -0.2909 | 2.6729 | 0.9872 | 1.11e-16 |
| HCC1143 | THZ531 | 0.129709951 | -0.2293 | 0.2435 | 0.1509 | -0.2433 | 2.6173 | 0.9825 | 1.11e-16 |
| HCC1395 | MK 1775 | 0.006597016 | -0.5660 | 0.8421 | 0.1385 | -0.8195 | 0.3187 | 0.9403 | 5.55e-16 |
| HCC1395 | AZD2014 | 0.010334257 | 0.1983 | 0.5546 | 0.0017 | 0.1495 | 0.1950 | 0.4827 | 0.000264203 |
| HCC1395 | AZD5363 | 0.139625415 | 0.1154 | 0.4931 | 78.2903 | -1.0000 | 0.1736 | 0.6229 | 5.07e-06 |
| HCC1395 | AZD6738 | -inf | -0.3125 |