Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | Senexin B | 1.759420996 | 0.3235 | 0.2847 | 157.3873 | -1.0000 | 0.2445 | 0.4951 | 0.000194933 |
| MDA-MB-361 | SHP099 | inf | 0.5804 | 0.1256 | 0.0000 | 0.8613 | 0.0100 | 0.0000 | 1.0 |
| MDA-MB-361 | THZ1 | 0.008546239 | -0.7383 | 0.6919 | 0.0322 | -0.9036 | 0.7783 | 0.9320 | 2.55e-15 |
| MDA-MB-361 | THZ531 | 0.027601073 | -0.5305 | 0.6318 | 0.0328 | -0.6914 | 5.0000 | 0.9478 | 1.11e-16 |
| MDA-MB-436 | MK 1775 | 0.189831078 | -0.2473 | 0.4933 | 6.7449 | -1.0000 | 0.3077 | 0.8316 | 2.13e-10 |
| MDA-MB-436 | AZD2014 | 55.44671225 | 0.5016 | 0.3680 | 0.0057 | 0.4275 | 0.2102 | 0.5733 | 2.38e-05 |
| MDA-MB-436 | AZD5363 | 392.3177575 | 0.6113 | 0.1390 | 65.2715 | 0.2186 | 0.3204 | 0.3405 | 0.005494124 |
| MDA-MB-436 | AZD6738 | -inf | |||||||
| MDA-MB-436 | BMS-265246 | 1.037326297 | 0.1940 | 0.3751 | 107.0431 | -1.0000 | 0.2369 | 0.8308 | 2.26e-10 |
| MDA-MB-436 | Ulixertinib | 34.76507133 | 0.5719 | 0.1213 | 534.6670 | -1.0000 | 0.4020 | 0.5984 | 1.11e-05 |
| MDA-MB-436 | Alvocidib | 0.162293194 | -0.0744 | 0.2528 | 0.1693 | -0.0464 | 2.0866 | 0.9251 | 8.55e-15 |
| MDA-MB-436 | GSK2334470 | 26.4830237 | 0.7307 | 0.0123 | 64.9192 | -0.9964 | 1.2226 | 0.3331 | 0.006324926 |
| MDA-MB-436 | Ribociclib | inf | 0.9493 | -0.0090 | 0.0000 | 1.0000 | 0.0100 | -0.0149 | 0.928505437 |
| MDA-MB-436 | LY3023414 | 4.691952741 | 0.1749 | 0.3897 | 1000.0000 | -0.3698 | 0.1033 | 0.4098 | 0.001372738 |
| MDA-MB-436 | RO-3306 | 4.603680516 | 0.0322 | 0.0603 | 4.5391 | 0.0341 | 5.0000 | 0.8979 | 4.12e-13 |
| MDA-MB-436 | Rucaparib | 0.828754457 | 0.1932 | 0.4025 | 792.8667 | -0.7731 | 0.1362 | 0.4480 | 0.00059396 |
| MDA-MB-436 | Senexin B | 8.766196947 | 0.4253 | 0.0969 | 24.2717 | -1.0000 | 1.0788 | 0.7057 | 2.29e-07 |
| MDA-MB-436 | SHP099 | inf | 0.8419 | -0.0182 | 0.0000 | 0.9962 | 0.0100 | 0.0000 | 0.527646554 |
| MDA-MB-436 | THZ1 | 0.134980364 | -0.1936 | 0.1828 | 0.1453 | -0.0697 | 1.7697 | 0.8946 | 6.07e-13 |
| MDA-MB-436 | THZ531 | 0.190775432 | 0.0195 | 0.1792 | 0.1975 | -0.0291 | 1.6412 | 0.8961 | 5.11e-13 |
| MDA-MB-453 | MK 1775 | 0.103540362 | -0.1845 | 0.5656 | 0.2626 | -0.3748 | 0.6010 | 0.9620 | 1.11e-16 |
| MDA-MB-453 | AZD2014 | 0.003343931 | 0.1648 | 0.6793 | 0.0016 | 0.1731 | 0.5548 | 0.7700 | 1.05e-08 |
| MDA-MB-453 | AZD5363 | 1.537709354 | 0.1686 | 0.2591 | 1.2036 | 0.0741 | 0.6549 | 0.8588 | 2.35e-11 |
| MDA-MB-453 | AZD6738 | 4.833057791 | -0.1286 | 0.1011 | 8.9747 | -1.0000 | 1.7750 | 0.9231 | 1.19e-14 |
| MDA-MB-453 | BMS-265246 | 0.757165765 | 0.2593 | 0.3794 | 214.7431 | -1.0000 | 0.1945 | 0.7673 | 1.21e-08 |