Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | AZD6738 | 8.215702739 | -0.0514 | -0.2134 | 10.2346 | -1.0000 | 5.0000 | 0.3830 | 0.000671245 |
| MDA-MB-157 | BMS-265246 | 0.001094371 | -0.2133 | 0.9099 | 0.0034 | -0.2455 | 0.3568 | 0.8223 | 4.17e-10 |
| MDA-MB-157 | Ulixertinib | -inf | 0.3233 | ||||||
| MDA-MB-157 | Alvocidib | 0.152222738 | -0.8658 | 0.2879 | 0.2794 | -1.0000 | 1.8087 | 0.9385 | 7.77e-16 |
| MDA-MB-157 | GSK2334470 | 76.35127426 | 0.4545 | 0.1687 | 498.7726 | -0.2137 | 0.1896 | 0.2637 | 0.021778256 |
| MDA-MB-157 | Ribociclib | inf | 0.5908 | 0.0808 | 0.0790 | 0.8320 | 5.0000 | 0.2263 | 0.040460682 |
| MDA-MB-157 | LY3023414 | 0.120671918 | -0.4605 | 0.5635 | 2.6226 | -1.0000 | 0.3568 | 0.8702 | 8.21e-12 |
| MDA-MB-157 | RO-3306 | 4.277636246 | -0.4568 | 0.0971 | 4.8761 | -0.4623 | 5.0000 | 0.8859 | 1.65e-12 |
| MDA-MB-157 | Rucaparib | 1.111762287 | 0.0267 | 0.3310 | 48.4687 | -1.0000 | 0.2910 | 0.5210 | 0.000101022 |
| MDA-MB-157 | Senexin B | 1.447945578 | -0.0499 | 0.2949 | 68.0631 | -1.0000 | 0.2853 | 0.5611 | 3.38e-05 |
| MDA-MB-157 | SHP099 | inf | 0.4006 | 0.1685 | 0.0000 | 0.8456 | 0.0100 | 0.0000 | 0.25024823 |
| MDA-MB-157 | THZ1 | 0.032181836 | -0.8998 | 0.5842 | 0.0485 | -0.8227 | 2.3777 | 0.9766 | 1.11e-16 |
| MDA-MB-157 | THZ531 | 0.060618587 | -0.7599 | 0.4261 | 0.0784 | -0.6567 | 3.2544 | 0.9596 | 1.11e-16 |
| MDA-MB-361 | MK 1775 | 0.005155215 | -0.3351 | 0.8878 | 0.0200 | -0.3972 | 0.4315 | 0.8532 | 3.83e-11 |
| MDA-MB-361 | AZD2014 | 0.000105775 | -0.6868 | 1.1635 | 0.0173 | -1.0000 | 0.2155 | 0.9146 | 4.4e-14 |
| MDA-MB-361 | AZD5363 | 0.749232388 | -0.4264 | 0.3226 | 5.9277 | -1.0000 | 0.5312 | 0.7585 | 1.93e-08 |
| MDA-MB-361 | AZD6738 | 4.823590174 | -0.2148 | 0.1657 | 8.6819 | -1.0000 | 1.8693 | 0.7060 | 2.26e-07 |
| MDA-MB-361 | BMS-265246 | -inf | 0.1856 | 0.5730 | 0.0000 | 0.4334 | 0.0100 | 0.0000 | 0.160494567 |
| MDA-MB-361 | Ulixertinib | 0.487697861 | 0.0501 | 0.2106 | 0.3084 | 0.4494 | 5.0000 | 0.6060 | 8.79e-06 |
| MDA-MB-361 | Alvocidib | 0.089713792 | -0.4956 | 0.4193 | 0.3494 | -1.0000 | 0.8080 | 0.8065 | 1.21e-09 |
| MDA-MB-361 | GSK2334470 | 0.050377803 | -0.4513 | 0.5704 | 2.8790 | -1.0000 | 0.2716 | 0.7322 | 7.05e-08 |
| MDA-MB-361 | Ribociclib | 0.00037253 | 0.1935 | 0.7764 | 0.0005 | -0.0324 | 0.2292 | 0.4761 | 0.000309356 |
| MDA-MB-361 | LY3023414 | 1.3e-05 | -0.9848 | 1.4263 | 0.0014 | -1.0000 | 0.2362 | 0.9070 | 1.28e-13 |
| MDA-MB-361 | RO-3306 | 5.850186547 | 0.0653 | 0.1084 | 11.6847 | -1.0000 | 1.5880 | 0.6865 | 5.05e-07 |
| MDA-MB-361 | Rucaparib | inf | 0.1133 | 0.3149 | 0.0128 | 0.5095 | 5.0000 | 0.3359 | 0.005993375 |