Breast Cancer Profiling Project, Drug Sensitivity phase II: Fixed-cell GR measures of 33 breast cell lines and PDX lines to 16 small molecule perturbagens from library plate II. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20355)
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| Cell | Small Molecule | GR50 | GRmax | GR_AOC | GEC50 | GRinf | GR Hill Coefficient | GR r2 | pval_GR |
|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | LY3023414 | 0.001726062 | 0.0262 | 0.6878 | 0.0014 | 0.0252 | 0.2428 | 0.8575 | 2.65e-11 |
| CAL-120 | RO-3306 | 8.527233934 | 0.1534 | 0.0250 | 10.6226 | -1.0000 | 5.0000 | 0.9423 | 3.33e-16 |
| CAL-120 | Rucaparib | 76.53871191 | 0.5903 | 0.1235 | 1000.0000 | -0.5462 | 0.2873 | 0.7153 | 1.52e-07 |
| CAL-120 | Senexin B | inf | 0.8437 | 0.1267 | 0.0000 | 0.8683 | 0.0100 | 0.0000 | 0.139800748 |
| CAL-120 | SHP099 | 13.63352074 | 0.7924 | 0.0042 | 16.9837 | -1.0000 | 5.0000 | 0.4392 | 0.000724955 |
| CAL-120 | THZ1 | -inf | -0.1577 | ||||||
| CAL-120 | THZ531 | 0.148031898 | -0.0605 | 0.1979 | 0.1679 | -0.0944 | 1.3725 | 0.9703 | 1.11e-16 |
| CAL-51 | MK 1775 | 0.310910353 | -0.1886 | 0.4395 | 4.9452 | -1.0000 | 0.3971 | 0.9792 | 1.11e-16 |
| CAL-51 | AZD2014 | 0.186060272 | 0.1980 | 0.4693 | 322.5046 | -1.0000 | 0.1473 | 0.9177 | 2.79e-14 |
| CAL-51 | AZD5363 | 30.19251597 | 0.5818 | 0.1493 | 1000.0000 | -0.8752 | 0.2890 | 0.7869 | 4.05e-09 |
| CAL-51 | AZD6738 | 5.499126795 | 0.0467 | 0.0977 | 10.8204 | -1.0000 | 1.6231 | 0.9631 | 1.11e-16 |
| CAL-51 | BMS-265246 | 4.166699159 | 0.3180 | 0.2124 | 83.7459 | -1.0000 | 0.3661 | 0.8327 | 1.96e-10 |
| CAL-51 | Ulixertinib | 20.08181132 | 0.7439 | 0.0569 | 48.1868 | -0.9997 | 1.2549 | 0.4674 | 0.000380369 |
| CAL-51 | Alvocidib | 0.203450964 | -0.1017 | 0.2311 | 0.8363 | -1.0000 | 0.7772 | 0.9758 | 1.11e-16 |
| CAL-51 | GSK2334470 | 22.73047392 | 0.8334 | 0.0336 | 53.5738 | -0.9998 | 1.2813 | 0.2592 | 0.023515658 |
| CAL-51 | Ribociclib | 3.77803891 | 0.3496 | 0.2868 | 766.6836 | -1.0000 | 0.2068 | 0.9334 | 2e-15 |
| CAL-51 | LY3023414 | 0.012387901 | -0.1180 | 0.6129 | 29.3234 | -1.0000 | 0.1414 | 0.7984 | 2.03e-09 |
| CAL-51 | RO-3306 | 8.346101408 | 0.1772 | 0.0379 | 11.9039 | -1.0000 | 3.0941 | 0.9243 | 9.77e-15 |
| CAL-51 | Rucaparib | 435.2054467 | 0.6520 | 0.0837 | 1000.0000 | -0.1445 | 0.3052 | 0.5584 | 3.65e-05 |
| CAL-51 | Senexin B | 49184874.89 | 0.7426 | 0.1286 | 1000.0000 | 0.4054 | 0.1541 | 0.2466 | 0.029016792 |
| CAL-51 | SHP099 | inf | 0.8600 | 0.0220 | 0.0000 | 0.9665 | 0.0100 | 0.0000 | 1.0 |
| CAL-51 | THZ1 | 0.398213883 | 0.0975 | 0.1363 | 1.3472 | -1.0000 | 0.9014 | 0.9402 | 5.55e-16 |
| CAL-51 | THZ531 | 1.43076633 | 0.5402 | 0.0683 | 0.9405 | 0.1606 | 0.9231 | 0.8600 | 2.12e-11 |
| CAL-85-1 | MK 1775 | 0.182874423 | -0.5298 | 0.5409 | 3.0854 | -1.0000 | 0.3888 | 0.7205 | 1.2e-07 |
| CAL-85-1 | AZD2014 | 0.006143702 | 0.1542 | 0.6519 | 0.0034 | 0.0732 | 0.2721 | 0.6523 | 1.84e-06 |