Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| Hs 578T | Trifluoperazine | 72 | 8.05469083899 | -0.4570 | 0.3243 | 10.8580 | -0.5129 | 2.3639 |
| Hs 578T | z-VAE(OMe)-fmk | 72 | inf | 0.9948 | 0.0176 | 0.0000 | 0.9832 | 0.0100 |
| MCF 10A | 1247825-37-1 | 72 | 7.50677192458 | -0.0271 | 0.2339 | 7.8926 | -0.0577 | 2.1809 |
| MCF 10A | USP7-IN-1 | 72 | 130.869645041 | 0.7420 | 0.0432 | 404.8308 | -0.8498 | 0.8794 |
| MCF 10A | GW7647 | 72 | 21.8868633466 | -0.1219 | 0.1105 | 23.6125 | -0.1775 | 4.0039 |
| MCF 10A | HBX19818 | 72 | 32.2419133513 | -0.1889 | 0.1089 | 44.8110 | -1.0000 | 3.3374 |
| MCF 10A | HBX 41108 | 72 | 0.57601885416 | -0.0685 | 0.5834 | 0.6298 | -0.1204 | 2.4159 |
| MCF 10A | HY-17541A | 72 | 17.9688754214 | -0.3960 | 0.1869 | 23.8178 | -0.5829 | 2.7426 |
| MCF 10A | HY-17542 | 72 | 122.726417103 | 0.9130 | 0.0108 | 200.5533 | -1.0000 | 2.2369 |
| MCF 10A | HY-50736 | 72 | 0.719497257196 | -0.1011 | 0.5489 | 0.7937 | -0.1109 | 2.0414 |
| MCF 10A | HY-50737A | 72 | 2.96132660648 | -0.0560 | 0.3759 | 3.0430 | -0.0720 | 4.9454 |
| MCF 10A | IU1 | 72 | inf | 0.9050 | 0.0119 | 30.9108 | 0.8598 | 1.4169 |
| MCF 10A | LDN57444 | 72 | 27.0792914711 | -0.1381 | 0.1203 | 45.1952 | -1.0000 | 2.1448 |
| MCF 10A | MI-2 | 72 | 5.79831624395 | -0.2953 | 0.3052 | 6.4633 | -0.2594 | 3.8494 |
| MCF 10A | ML-323 | 72 | 66.3873318694 | 0.5514 | 0.0860 | 333.5126 | -1.0000 | 0.6806 |
| MCF 10A | Pevonedistat | 72 | 0.283189283641 | -0.1451 | 0.6453 | 0.3283 | -0.1036 | 1.2735 |
| MCF 10A | PB49673382 | 72 | 5.3905505782 | 0.0428 | 0.2622 | 5.1937 | 0.0339 | 1.8897 |
| MCF 10A | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | 738.9217363 | 0.8943 | 0.0150 | 255.4365 | 0.3311 | 1.0216 |
| MCF 10A | SB1-F-21 | 72 | 0.955974486321 | -0.3618 | 0.5752 | 1.3326 | -0.3618 | 1.6390 |
| MCF 10A | SB1-F-22 | 72 | inf | 0.6491 | 0.0559 | 11.0527 | 0.6904 | 5.0000 |
| MCF 10A | SJB2-043 | 72 | 0.862612545381 | -0.1149 | 0.4174 | 0.9321 | -0.1040 | 2.4388 |
| MCF 10A | SJB3-019A | 72 | 0.405445696252 | -0.1954 | 0.6695 | 0.4504 | -0.1982 | 3.1747 |
| MCF 10A | STK547622 | 72 | inf | 1.0022 | -0.0053 | 0.0000 | 1.0000 | 0.0100 |
| MCF 10A | Vialinin A | 72 | 12.7930209016 | -0.2051 | 0.1740 | 13.7221 | -0.2088 | 4.9768 |
| MCF 10A | Degrasyn | 72 | 1.40857817808 | -0.1567 | 0.4917 | 1.5039 | -0.1937 | 5.0000 |