Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDXHCI002 | b-AP15 | 72 | 0.0451916121201 | -0.5737 | 1.1338 | 0.0762 | -0.5135 | 1.3527 |
| PDXHCI002 | Doxycycline | 72 | inf | 0.8165 | 0.0542 | 0.0000 | 0.9159 | 0.0100 |
| PDXHCI002 | Mitoxantrone | 72 | 0.000170736912028 | -0.5642 | 1.3538 | 0.0014 | -0.5519 | 0.3578 |
| PDXHCI002 | P22077 | 72 | 10.7479118489 | -0.5061 | 0.2448 | 17.0137 | -0.7180 | 1.9385 |
| PDXHCI002 | Pimozide | 72 | 3.73166784701 | -0.4762 | 0.4161 | 6.9559 | -0.6294 | 1.3085 |
| PDXHCI002 | Spautin-1 | 72 | inf | 0.6681 | 0.0442 | 16.2331 | 0.6233 | 1.8836 |
| PDXHCI002 | Trifluoperazine | 72 | 3.81665897006 | -0.5151 | 0.4939 | 4.3815 | -0.4970 | 5.0000 |
| PDXHCI002 | z-VAE(OMe)-fmk | 72 | inf | 0.9278 | 0.0585 | 0.0000 | 0.9445 | 0.0100 |
| SK-BR-3 | 1247825-37-1 | 72 | 8.5852333914 | -0.0647 | 0.2610 | 8.9503 | -0.0631 | 2.8528 |
| SK-BR-3 | USP7-IN-1 | 72 | 62.2210904101 | 0.5764 | 0.0588 | 133.0943 | -1.0000 | 1.4449 |
| SK-BR-3 | GW7647 | 72 | 63.3177975853 | 0.6434 | 0.0223 | 112.2791 | -1.0000 | 1.9179 |
| SK-BR-3 | HBX19818 | 72 | 16.5240512414 | -0.5295 | 0.1906 | 30.2429 | -1.0000 | 1.8176 |
| SK-BR-3 | HBX 41108 | 72 | 0.707551662904 | -0.6033 | 0.6328 | 2.3097 | -0.7141 | 0.7499 |
| SK-BR-3 | HY-17541A | 72 | 6.05256867179 | -0.8127 | 0.3348 | 15.3356 | -1.0000 | 1.1817 |
| SK-BR-3 | HY-17542 | 72 | inf | 0.8550 | 0.0387 | 0.0000 | 0.9480 | 0.0100 |
| SK-BR-3 | HY-50736 | 72 | 0.115680810144 | -0.4176 | 0.9862 | 0.1504 | -0.4466 | 2.4308 |
| SK-BR-3 | HY-50737A | 72 | 0.478741799562 | -0.5895 | 0.7685 | 0.6829 | -0.5240 | 2.0185 |
| SK-BR-3 | IU1 | 72 | 206.741150231 | 0.7547 | 0.0343 | 99.4820 | 0.2546 | 0.9732 |
| SK-BR-3 | LDN57444 | 72 | 22.3408232354 | 0.2285 | 0.1807 | 104.9983 | -1.0000 | 0.7099 |
| SK-BR-3 | MI-2 | 72 | 0.671480855708 | -0.7413 | 0.8062 | 0.9689 | -0.7037 | 2.3958 |
| SK-BR-3 | ML-323 | 72 | 71.5457262907 | 0.6083 | 0.0659 | 250.9976 | -1.0000 | 0.8753 |
| SK-BR-3 | Pevonedistat | 72 | 0.0849225267347 | 0.0282 | 0.7128 | 0.0790 | 0.0487 | 1.4169 |
| SK-BR-3 | PB49673382 | 72 | 4.13146034734 | 0.0664 | 0.3312 | 3.9132 | 0.0565 | 2.2078 |
| SK-BR-3 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9496 | 0.0325 | 0.0000 | 0.9679 | 0.0100 |
| SK-BR-3 | SB1-F-21 | 72 | 0.26463962594 | -0.4562 | 0.7702 | 0.4655 | -0.4299 | 1.0988 |