Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1328 | z-VAE(OMe)-fmk | 72 | inf | 1.0551 | 0.0297 | 0.0000 | 0.9884 | 0.0100 |
| PDXHCI002 | 1247825-37-1 | 72 | 7.7918126167 | -0.2501 | 0.2337 | 8.8742 | -0.2609 | 3.2282 |
| PDXHCI002 | USP7-IN-1 | 72 | inf | 0.8827 | 0.0691 | 0.0000 | 0.9313 | 0.0100 |
| PDXHCI002 | GW7647 | 72 | inf | 0.7629 | -0.0251 | 0.0000 | 0.9997 | 0.0100 |
| PDXHCI002 | HBX19818 | 72 | 11.6902936105 | -0.5250 | 0.2522 | 14.0123 | -0.5432 | 4.0591 |
| PDXHCI002 | HBX 41108 | 72 | 0.569584571739 | -0.3596 | 0.6226 | 0.9572 | -0.3632 | 1.0518 |
| PDXHCI002 | HY-17541A | 72 | 5.47225294247 | -0.5597 | 0.3450 | 15.9936 | -1.0000 | 1.0243 |
| PDXHCI002 | HY-17542 | 72 | inf | 0.9564 | 0.0027 | 0.0000 | 0.9920 | 0.0100 |
| PDXHCI002 | HY-50736 | 72 | 0.868083561962 | -0.2659 | 0.6264 | 1.0125 | -0.3271 | 3.2699 |
| PDXHCI002 | HY-50737A | 72 | 11.4596842357 | -0.3785 | 0.2045 | 23.6412 | -0.8333 | 1.3544 |
| PDXHCI002 | IU1 | 72 | inf | 0.7347 | 0.0713 | 0.0000 | 0.9096 | 0.0100 |
| PDXHCI002 | LDN57444 | 72 | inf | 0.3570 | 0.1453 | 0.0000 | 0.8080 | 0.0100 |
| PDXHCI002 | MI-2 | 72 | 2.07981662883 | -0.4502 | 0.5052 | 2.6497 | -0.4714 | 2.7423 |
| PDXHCI002 | ML-323 | 72 | 17.8247031142 | 0.1781 | 0.1858 | 109.9820 | -1.0000 | 0.6037 |
| PDXHCI002 | Pevonedistat | 72 | 0.0433461990142 | -0.5207 | 1.1704 | 0.0659 | -0.5145 | 1.6896 |
| PDXHCI002 | PB49673382 | 72 | 23.2849540906 | -0.0464 | 0.1415 | 59.6753 | -1.0000 | 1.1674 |
| PDXHCI002 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9950 | 0.1063 | 0.0000 | 0.9127 | 0.0100 |
| PDXHCI002 | SB1-F-21 | 72 | 0.621844255197 | -0.4582 | 0.6580 | 0.9577 | -0.4592 | 1.5086 |
| PDXHCI002 | SB1-F-22 | 72 | inf | 0.7782 | 0.0455 | 4.9366 | 0.7857 | 0.8521 |
| PDXHCI002 | SJB2-043 | 72 | 0.744329070426 | -0.3405 | 0.5118 | 0.9155 | -0.3386 | 2.4985 |
| PDXHCI002 | SJB3-019A | 72 | 0.305258876445 | -0.5784 | 0.8656 | 0.4150 | -0.5629 | 2.4552 |
| PDXHCI002 | STK547622 | 72 | inf | 0.9789 | 0.0218 | 0.0000 | 0.9934 | 0.0100 |
| PDXHCI002 | Vialinin A | 72 | 7.00727645507 | -0.4803 | 0.2922 | 11.4231 | -0.6362 | 1.6797 |
| PDXHCI002 | Degrasyn | 72 | 1.85435730216 | -0.6095 | 0.6125 | 2.8224 | -0.6043 | 1.8864 |
| PDXHCI002 | Sepantronium | 72 | 0.0830755783448 | -0.5798 | 1.0081 | 0.1289 | -0.4748 | 1.5187 |