Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | HBX 41108 | 72 | 0.515725968644 | -0.7549 | 0.7581 | 1.8602 | -0.8858 | 0.7947 |
| HCC1419 | HY-17541A | 72 | 5.08410753288 | -0.7228 | 0.3771 | 13.2847 | -1.0000 | 1.1438 |
| HCC1419 | HY-17542 | 72 | inf | 0.8046 | 0.0234 | 7.3179 | 0.8511 | 5.0000 |
| HCC1419 | HY-50736 | 72 | 0.0489088737336 | -0.6741 | 1.2774 | 0.0889 | -0.7080 | 1.4773 |
| HCC1419 | HY-50737A | 72 | 0.231678580625 | -0.6762 | 0.9645 | 0.4319 | -0.6991 | 1.4044 |
| HCC1419 | IU1 | 72 | inf | 0.6981 | 0.0438 | 17.0535 | 0.7480 | 5.0000 |
| HCC1419 | LDN57444 | 72 | 23.1466968338 | -0.3740 | 0.1147 | 36.5806 | -1.0000 | 2.4005 |
| HCC1419 | MI-2 | 72 | 0.8507722389 | -0.5904 | 0.7165 | 1.0642 | -0.5907 | 3.4840 |
| HCC1419 | ML-323 | 72 | 19.6035773316 | 0.0958 | 0.1509 | 30.3213 | -0.4046 | 1.3594 |
| HCC1419 | Pevonedistat | 72 | 0.633958608318 | -0.0652 | 0.4905 | 0.6588 | -0.0594 | 2.9213 |
| HCC1419 | PB49673382 | 72 | 5.75380160264 | 0.0084 | 0.2491 | 5.7215 | 0.0090 | 3.2180 |
| HCC1419 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9816 | -0.0058 | 0.0000 | 1.0000 | 0.0100 |
| HCC1419 | SB1-F-21 | 72 | 0.663926023368 | -0.4674 | 0.6317 | 0.8296 | -0.3694 | 2.4827 |
| HCC1419 | SB1-F-22 | 72 | 16.9369859078 | 0.2855 | 0.1259 | 10.0959 | 0.3307 | 2.0935 |
| HCC1419 | SJB2-043 | 72 | 0.513272955065 | -0.6875 | 0.6450 | 0.9630 | -0.7220 | 1.4201 |
| HCC1419 | SJB3-019A | 72 | 0.264021428661 | -0.7295 | 0.9719 | 0.3757 | -0.7072 | 2.4982 |
| HCC1419 | STK547622 | 72 | inf | 1.0781 | 0.0128 | 0.0000 | 1.0000 | 0.0100 |
| HCC1419 | Vialinin A | 72 | 6.52356293031 | -0.5490 | 0.2630 | 13.1152 | -0.7812 | 1.3473 |
| HCC1419 | Degrasyn | 72 | 2.04026623653 | -0.7805 | 0.5512 | 2.7698 | -0.7166 | 2.9086 |
| HCC1419 | Sepantronium | 72 | 0.0796965605305 | -0.7110 | 1.1081 | 0.1781 | -0.6956 | 1.0840 |
| HCC1419 | b-AP15 | 72 | 0.193977861969 | -0.7204 | 0.9296 | 0.4205 | -0.7037 | 1.1355 |
| HCC1419 | Doxycycline | 72 | 29.9947198826 | 0.0713 | 0.0985 | 58.5488 | -1.0000 | 1.6426 |
| HCC1419 | Mitoxantrone | 72 | 0.0324309949523 | -0.8993 | 1.0606 | 0.5551 | -1.0000 | 0.3868 |
| HCC1419 | P22077 | 72 | 8.76132440873 | -0.6824 | 0.2499 | 11.6302 | -0.7166 | 3.1394 |
| HCC1419 | Pimozide | 72 | 6.13162921953 | -0.7003 | 0.3602 | 13.2581 | -1.0000 | 1.4246 |