Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1419 | Spautin-1 | 72 | 4.87236648112 | 0.2290 | 0.2386 | 3.5270 | 0.2325 | 1.9354 |
| HCC1419 | Trifluoperazine | 72 | 10.5203345948 | -0.7163 | 0.2648 | 14.1951 | -0.7605 | 3.0865 |
| HCC1419 | z-VAE(OMe)-fmk | 72 | inf | 0.9275 | 0.0463 | 0.0000 | 0.9622 | 0.0100 |
| HCC1428 | 1247825-37-1 | 72 | 4.93495492588 | -0.2477 | 0.3384 | 6.4761 | -0.2632 | 1.5561 |
| HCC1428 | USP7-IN-1 | 72 | inf | 0.6846 | 0.0667 | 0.0000 | 0.9252 | 0.0100 |
| HCC1428 | GW7647 | 72 | inf | 0.6988 | -0.0012 | 0.0000 | 0.9685 | 0.0100 |
| HCC1428 | HBX19818 | 72 | 11.3560823948 | -0.6631 | 0.2445 | 21.0348 | -1.0000 | 1.7822 |
| HCC1428 | HBX 41108 | 72 | 0.0712282775341 | -0.6506 | 1.0708 | 0.1364 | -0.5624 | 1.1606 |
| HCC1428 | HY-17541A | 72 | 2.47757925824 | -0.8052 | 0.5062 | 7.7740 | -1.0000 | 0.9607 |
| HCC1428 | HY-17542 | 72 | inf | 0.7557 | 0.0179 | 0.0000 | 0.9697 | 0.0100 |
| HCC1428 | HY-50736 | 72 | 0.00717425961123 | -0.6124 | 1.6421 | 0.0111 | -0.7153 | 2.0173 |
| HCC1428 | HY-50737A | 72 | 0.0382137561414 | -0.7451 | 1.3903 | 0.0607 | -0.7570 | 1.9896 |
| HCC1428 | IU1 | 72 | inf | 0.7506 | 0.0316 | 0.0000 | 0.9483 | 0.0100 |
| HCC1428 | LDN57444 | 72 | 12.549009736 | -0.0136 | 0.2378 | 89.8320 | -1.0000 | 0.5582 |
| HCC1428 | MI-2 | 72 | 1.03571191058 | -0.7986 | 0.7440 | 1.3395 | -0.7690 | 3.6211 |
| HCC1428 | ML-323 | 72 | inf | 0.5825 | 0.1106 | 1.0330 | 0.6949 | 2.4444 |
| HCC1428 | Pevonedistat | 72 | 0.0551476845561 | -0.1563 | 0.9412 | 0.0662 | -0.1995 | 1.8358 |
| HCC1428 | PB49673382 | 72 | 7.01354580048 | -0.0082 | 0.2607 | 6.7113 | 0.0347 | 1.6331 |
| HCC1428 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9183 | 0.0941 | 0.0000 | 0.9165 | 0.0100 |
| HCC1428 | SB1-F-21 | 72 | 0.390716798135 | -0.7458 | 0.8486 | 0.7302 | -0.7362 | 1.4476 |
| HCC1428 | SB1-F-22 | 72 | 31.0121984952 | 0.4228 | 0.0852 | 13.1557 | 0.3067 | 1.1083 |
| HCC1428 | SJB2-043 | 72 | 0.829968735356 | -0.6237 | 0.5416 | 1.3763 | -0.6396 | 1.6289 |
| HCC1428 | SJB3-019A | 72 | 0.367074889212 | -0.7873 | 0.9956 | 0.4852 | -0.7833 | 3.3771 |
| HCC1428 | STK547622 | 72 | inf | 0.8677 | 0.0634 | 0.0000 | 0.9587 | 0.0100 |
| HCC1428 | Vialinin A | 72 | 7.02266916467 | -0.5218 | 0.2922 | 19.4033 | -1.0000 | 1.0810 |