Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MCF 10A | Sepantronium | 72 | 0.00774537160659 | -0.1459 | 1.0865 | 0.0087 | -0.1294 | 1.9809 |
| MCF 10A | b-AP15 | 72 | 0.247307753993 | -0.2223 | 0.7451 | 0.2767 | -0.2064 | 3.0780 |
| MCF 10A | Doxycycline | 72 | 17.5607328555 | 0.0611 | 0.1936 | 17.6072 | -0.0035 | 2.6522 |
| MCF 10A | Mitoxantrone | 72 | 0.017667155736 | -0.2638 | 0.9981 | 0.0292 | -0.2233 | 0.7335 |
| MCF 10A | P22077 | 72 | 4.7951144345 | -0.3461 | 0.3384 | 5.2700 | -0.2789 | 4.6944 |
| MCF 10A | Pimozide | 72 | 16.0216158403 | -0.1385 | 0.1713 | 17.8369 | -0.1921 | 3.0288 |
| MCF 10A | Spautin-1 | 72 | inf | 0.7020 | 0.0777 | 4.4596 | 0.7090 | 1.5877 |
| MCF 10A | Trifluoperazine | 72 | 13.7054527208 | -0.3753 | 0.2032 | 15.3336 | -0.3764 | 5.0000 |
| MCF 10A | z-VAE(OMe)-fmk | 72 | inf | 0.9979 | 0.0012 | 0.0000 | 0.9999 | 0.0100 |
| MCF7 | 1247825-37-1 | 72 | 11.3527817708 | -0.0635 | 0.1793 | 13.0348 | -0.1527 | 1.9288 |
| MCF7 | USP7-IN-1 | 72 | inf | 0.6288 | 0.0309 | 31.6085 | 0.5581 | 3.6163 |
| MCF7 | GW7647 | 72 | 67.0602654387 | 0.8376 | -0.0104 | 77.7420 | -0.5174 | 4.8064 |
| MCF7 | HBX19818 | 72 | 22.3259717989 | -0.2798 | 0.1315 | 35.8197 | -0.8671 | 2.1277 |
| MCF7 | HBX 41108 | 72 | 0.390147535667 | -0.2149 | 0.6730 | 0.5376 | -0.2563 | 1.2906 |
| MCF7 | HY-17541A | 72 | 7.73553288527 | -0.3502 | 0.2614 | 22.0378 | -0.9606 | 1.0240 |
| MCF7 | HY-17542 | 72 | inf | 0.9160 | 0.0071 | 30.5166 | 0.9088 | 5.0000 |
| MCF7 | HY-50736 | 72 | 0.048225043242 | -0.1348 | 0.9464 | 0.0630 | -0.2053 | 1.2899 |
| MCF7 | HY-50737A | 72 | 0.230613494355 | -0.1986 | 0.7394 | 0.3067 | -0.2336 | 1.3443 |
| MCF7 | IU1 | 72 | inf | 0.7464 | 0.0252 | 29.2117 | 0.7291 | 5.0000 |
| MCF7 | LDN57444 | 72 | 39.229352909 | 0.3803 | 0.0338 | 32.3166 | 0.3103 | 5.0000 |
| MCF7 | MI-2 | 72 | 6.8346316028 | -0.3570 | 0.2990 | 9.1547 | -0.4209 | 2.0896 |
| MCF7 | ML-323 | 72 | 34.9041902184 | 0.3934 | 0.1213 | 138.0045 | -1.0000 | 0.7992 |
| MCF7 | Pevonedistat | 72 | 0.150383057079 | -0.0374 | 0.6766 | 0.1518 | -0.0061 | 1.3103 |
| MCF7 | PB49673382 | 72 | 5.67599742388 | -0.0650 | 0.2629 | 5.9577 | -0.0564 | 2.2057 |
| MCF7 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0084 | -0.0062 | 0.0000 | 1.0000 | 0.0100 |