Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1428 | Degrasyn | 72 | 1.70453075174 | -0.8048 | 0.5951 | 3.0602 | -0.7743 | 1.5987 |
| HCC1428 | Sepantronium | 72 | 0.00658980680929 | -0.7607 | 1.4822 | 0.0245 | -0.7925 | 0.7235 |
| HCC1428 | b-AP15 | 72 | 0.0647974209893 | -0.7164 | 1.1058 | 0.1041 | -0.5730 | 1.6094 |
| HCC1428 | Doxycycline | 72 | inf | 0.5312 | 0.1526 | 0.0000 | 0.8018 | 0.0100 |
| HCC1428 | Mitoxantrone | 72 | 0.00295749777894 | -0.6226 | 1.3027 | 0.0198 | -0.6386 | 0.4326 |
| HCC1428 | P22077 | 72 | 3.38223139313 | -0.8186 | 0.5185 | 5.0583 | -0.8189 | 2.4098 |
| HCC1428 | Pimozide | 72 | 5.48832397235 | -0.7126 | 0.4005 | 12.0349 | -1.0000 | 1.3992 |
| HCC1428 | Spautin-1 | 72 | 68.801118056 | 0.5372 | 0.0887 | 19.5936 | 0.3315 | 0.8660 |
| HCC1428 | Trifluoperazine | 72 | 7.02071798246 | -0.7839 | 0.3754 | 12.0126 | -0.9425 | 1.9727 |
| HCC1428 | z-VAE(OMe)-fmk | 72 | inf | 0.9944 | 0.0566 | 0.0000 | 0.9577 | 0.0100 |
| HCC1500 | 1247825-37-1 | 72 | 9.28838157031 | -0.3852 | 0.2439 | 10.3909 | -0.3761 | 5.0000 |
| HCC1500 | USP7-IN-1 | 72 | 51.9923039456 | 0.4861 | 0.0630 | 130.5080 | -1.0000 | 1.1937 |
| HCC1500 | GW7647 | 72 | 42.1427904431 | 0.1820 | -0.0218 | 72.6766 | -0.9087 | 1.9008 |
| HCC1500 | HBX19818 | 72 | 15.1685808671 | -0.6194 | 0.2142 | 22.6040 | -0.8501 | 2.4902 |
| HCC1500 | HBX 41108 | 72 | 0.412675281224 | -0.5160 | 0.7064 | 2.6426 | -0.8455 | 0.5331 |
| HCC1500 | HY-17541A | 72 | 6.22982678245 | -0.6101 | 0.3035 | 17.0198 | -1.0000 | 1.0931 |
| HCC1500 | HY-17542 | 72 | 139.024096434 | 0.7326 | 0.0159 | 49.2255 | 0.4705 | 2.7249 |
| HCC1500 | HY-50736 | 72 | 0.0190327200366 | -0.5028 | 1.3866 | 0.0297 | -0.5913 | 1.7553 |
| HCC1500 | HY-50737A | 72 | 0.114212661737 | -0.5828 | 1.0742 | 0.1811 | -0.6211 | 1.7514 |
| HCC1500 | IU1 | 72 | inf | 0.6977 | 0.0082 | 0.0000 | 0.9531 | 0.0100 |
| HCC1500 | LDN57444 | 72 | 39.3689454794 | 0.2463 | 0.0822 | 61.7679 | -1.0000 | 2.4392 |
| HCC1500 | MI-2 | 72 | 1.03863229142 | -0.5157 | 0.6463 | 1.2257 | -0.4602 | 3.9408 |
| HCC1500 | ML-323 | 72 | 22.8896968406 | 0.1643 | 0.1263 | 77.3652 | -1.0000 | 0.9021 |
| HCC1500 | Pevonedistat | 72 | 0.137214417377 | 0.1450 | 0.5633 | 0.0907 | 0.2227 | 1.4231 |
| HCC1500 | PB49673382 | 72 | 2.15663277537 | -0.3642 | 0.4919 | 3.0687 | -0.4022 | 1.6734 |