Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1500 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0783 | 0.0024 | 0.0000 | 0.9998 | 0.0100 |
| HCC1500 | SB1-F-21 | 72 | 0.30399978751 | -0.4684 | 0.8004 | 0.4116 | -0.4456 | 2.1021 |
| HCC1500 | SB1-F-22 | 72 | 8.98637669492 | 0.0425 | 0.2068 | 10.2676 | -0.0717 | 1.0048 |
| HCC1500 | SJB2-043 | 72 | 0.201434109876 | -0.4925 | 0.7459 | 0.2844 | -0.4547 | 1.8761 |
| HCC1500 | SJB3-019A | 72 | 0.111463571386 | -0.5985 | 1.0350 | 0.1889 | -0.5857 | 1.4704 |
| HCC1500 | STK547622 | 72 | inf | 0.8453 | 0.0394 | 0.0000 | 0.9715 | 0.0100 |
| HCC1500 | Vialinin A | 72 | 6.94264500958 | -0.4158 | 0.2869 | 11.1402 | -0.5530 | 1.5750 |
| HCC1500 | Degrasyn | 72 | 1.3319409029 | -0.5824 | 0.5931 | 1.7551 | -0.5299 | 2.6195 |
| HCC1500 | Sepantronium | 72 | 0.48222369882 | -0.6675 | 0.7593 | 0.9213 | -0.6468 | 1.2822 |
| HCC1500 | b-AP15 | 72 | 0.166633438938 | -0.5813 | 0.9654 | 0.2171 | -0.5410 | 2.7718 |
| HCC1500 | Doxycycline | 72 | 22.0862589106 | -0.3863 | 0.1938 | 36.1548 | -1.0000 | 2.2291 |
| HCC1500 | Mitoxantrone | 72 | 0.0111833408416 | -0.4904 | 1.0596 | 0.0246 | -0.2899 | 0.5795 |
| HCC1500 | P22077 | 72 | 9.09185293504 | -0.4885 | 0.2828 | 14.4725 | -0.6763 | 1.8403 |
| HCC1500 | Pimozide | 72 | 6.78743066265 | -0.5563 | 0.3689 | 15.8355 | -1.0000 | 1.2968 |
| HCC1500 | Spautin-1 | 72 | 3.41360576159 | -0.0935 | 0.3577 | 5.5741 | -0.2758 | 0.8959 |
| HCC1500 | Trifluoperazine | 72 | 6.81100307422 | -0.8014 | 0.3931 | 10.4325 | -0.8483 | 2.3266 |
| HCC1500 | z-VAE(OMe)-fmk | 72 | inf | 1.1021 | 0.0136 | 0.0000 | 1.0000 | 0.0100 |
| HCC1806 | 1247825-37-1 | 72 | 9.12829214245 | -0.2678 | 0.2475 | 11.9984 | -0.3697 | 2.0245 |
| HCC1806 | USP7-IN-1 | 72 | 154.815652356 | 0.8197 | 0.0286 | 421.1954 | -1.0000 | 1.0977 |
| HCC1806 | GW7647 | 72 | 27.3770374982 | -0.1520 | 0.0802 | 45.8792 | -0.9327 | 2.0389 |
| HCC1806 | HBX19818 | 72 | 25.9394145036 | -0.2844 | 0.1046 | 40.7861 | -0.9271 | 2.3174 |
| HCC1806 | HBX 41108 | 72 | 1.89335739104 | -0.2790 | 0.4749 | 2.4303 | -0.2907 | 1.8354 |
| HCC1806 | HY-17541A | 72 | 13.4077616893 | -0.6698 | 0.2684 | 22.7925 | -1.0000 | 2.0705 |
| HCC1806 | HY-17542 | 72 | inf | 0.9036 | 0.0149 | 0.0000 | 0.9763 | 0.0100 |
| HCC1806 | HY-50736 | 72 | 1.83055549594 | -0.3620 | 0.4984 | 2.5312 | -0.3697 | 1.7079 |