Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-549 | SJB2-043 | 72 | 0.795024880409 | -0.3792 | 0.5237 | 0.9638 | -0.3726 | 2.8926 |
| BT-549 | SJB3-019A | 72 | 0.339491273677 | -0.3726 | 0.8009 | 0.3799 | -0.3779 | 5.0000 |
| BT-549 | STK547622 | 72 | inf | 0.9826 | 0.0068 | 0.0000 | 0.9966 | 0.0100 |
| BT-549 | Vialinin A | 72 | 10.2995235466 | -0.3417 | 0.2294 | 12.2594 | -0.3642 | 3.1415 |
| BT-549 | Degrasyn | 72 | 2.03345345035 | -0.2544 | 0.4762 | 2.2668 | -0.2681 | 3.9517 |
| BT-549 | Sepantronium | 72 | 0.0268606049638 | -0.4073 | 1.1453 | 0.0366 | -0.3708 | 1.7888 |
| BT-549 | b-AP15 | 72 | 0.135351703688 | -0.3599 | 0.8972 | 0.1669 | -0.3392 | 2.4711 |
| BT-549 | Doxycycline | 72 | 16.3310783662 | -0.1425 | 0.1726 | 19.1261 | -0.2467 | 2.5386 |
| BT-549 | Mitoxantrone | 72 | 0.0348124463112 | -0.5149 | 1.0122 | 0.0911 | -0.4314 | 0.6469 |
| BT-549 | P22077 | 72 | 15.5619099885 | -0.2638 | 0.1622 | 17.6412 | -0.2914 | 3.6612 |
| BT-549 | Pimozide | 72 | 12.900272139 | -0.4203 | 0.2457 | 17.3340 | -0.5372 | 2.4698 |
| BT-549 | Spautin-1 | 72 | inf | 0.6348 | 0.1075 | 13.3350 | 0.5009 | 0.6856 |
| BT-549 | Trifluoperazine | 72 | 15.935091597 | -0.6252 | 0.2021 | 21.7254 | -0.7609 | 2.9843 |
| BT-549 | z-VAE(OMe)-fmk | 72 | inf | 0.9727 | 0.0182 | 0.0000 | 0.9828 | 0.0100 |
| CAMA-1 | 1247825-37-1 | 72 | 12.5263467336 | -0.2434 | 0.1646 | 13.4850 | -0.2229 | 5.0000 |
| CAMA-1 | USP7-IN-1 | 72 | 90.407874652 | 0.7005 | 0.0265 | 239.6012 | -1.0000 | 1.1272 |
| CAMA-1 | GW7647 | 72 | 51.1807184271 | 0.5179 | 0.0238 | 80.0691 | -0.9662 | 2.4039 |
| CAMA-1 | HBX19818 | 72 | 24.9121589631 | -0.4378 | 0.1232 | 36.6256 | -1.0000 | 2.8506 |
| CAMA-1 | HBX 41108 | 72 | 0.0470901366866 | -0.3783 | 1.0375 | 0.0808 | -0.3961 | 1.0796 |
| CAMA-1 | HY-17541A | 72 | 7.52712235452 | -0.7494 | 0.2920 | 17.5656 | -1.0000 | 1.2964 |
| CAMA-1 | HY-17542 | 72 | inf | 0.8374 | 0.0179 | 0.0000 | 0.9681 | 0.0100 |
| CAMA-1 | HY-50736 | 72 | 0.00740329650359 | -0.4438 | 1.4260 | 0.0096 | -0.4747 | 2.5511 |
| CAMA-1 | HY-50737A | 72 | 0.0398550490328 | -0.3484 | 1.1830 | 0.0537 | -0.4527 | 2.1642 |
| CAMA-1 | IU1 | 72 | inf | 0.7385 | 0.0833 | 0.9170 | 0.8015 | 5.0000 |
| CAMA-1 | LDN57444 | 72 | 2.83119526 | -0.3122 | 0.4296 | 3.1629 | -0.2963 | 4.2007 |