Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC202 | ML-323 | 72 | inf | 0.5409 | 0.1086 | 0.9673 | 0.7036 | 5.0000 |
| HCC202 | Pevonedistat | 72 | 0.22686190551 | -0.1206 | 0.6609 | 0.2532 | -0.0750 | 1.2710 |
| HCC202 | PB49673382 | 72 | 5.94545205071 | 0.0754 | 0.2337 | 5.4906 | 0.1376 | 4.0443 |
| HCC202 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.7899 | 0.0919 | 0.0000 | 0.9166 | 0.0100 |
| HCC202 | SB1-F-21 | 72 | 0.441545872924 | -0.7837 | 0.7543 | 0.9431 | -0.7246 | 1.1804 |
| HCC202 | SB1-F-22 | 72 | inf | 0.5140 | 0.0137 | 13.2393 | 0.5091 | 4.4104 |
| HCC202 | SJB2-043 | 72 | 0.34979801402 | -0.6438 | 0.6718 | 0.6597 | -0.6491 | 1.3117 |
| HCC202 | SJB3-019A | 72 | 0.309480434729 | -0.7379 | 0.9677 | 0.4087 | -0.7302 | 3.2363 |
| HCC202 | STK547622 | 72 | inf | 0.8807 | 0.0217 | 0.0000 | 0.9799 | 0.0100 |
| HCC202 | Vialinin A | 72 | 7.85110394178 | -0.4245 | 0.2333 | 14.2814 | -0.5846 | 1.2943 |
| HCC202 | Degrasyn | 72 | 2.90526057295 | -0.6923 | 0.5131 | 3.4402 | -0.6640 | 5.0000 |
| HCC202 | Sepantronium | 72 | 0.0290947525156 | -0.7576 | 1.3115 | 0.0737 | -0.7522 | 0.9876 |
| HCC202 | b-AP15 | 72 | 0.101469191263 | -0.7256 | 1.0819 | 0.1809 | -0.6658 | 1.4645 |
| HCC202 | Doxycycline | 72 | 41.0834372075 | 0.2347 | 0.0694 | 58.6649 | -1.0000 | 3.0839 |
| HCC202 | Mitoxantrone | 72 | 0.00434457297625 | -0.7112 | 1.2184 | 0.1443 | -1.0000 | 0.3136 |
| HCC202 | P22077 | 72 | 9.91449173635 | -0.8050 | 0.3064 | 12.0209 | -0.8101 | 5.0000 |
| HCC202 | Pimozide | 72 | 12.1529447858 | -0.5717 | 0.2693 | 15.7689 | -0.6442 | 3.1784 |
| HCC202 | Spautin-1 | 72 | 29.2225686874 | 0.3956 | 0.1067 | 10.7821 | 0.3657 | 1.3182 |
| HCC202 | Trifluoperazine | 72 | 10.0332245014 | -0.8634 | 0.3175 | 14.5499 | -0.9578 | 2.8790 |
| HCC202 | z-VAE(OMe)-fmk | 72 | inf | 1.0085 | 0.0421 | 0.0000 | 0.9739 | 0.0100 |
| Hs 578T | 1247825-37-1 | 72 | 10.9138626563 | -0.3555 | 0.2306 | 11.9637 | -0.2914 | 5.0000 |
| Hs 578T | USP7-IN-1 | 72 | inf | 0.8486 | 0.0005 | 0.0000 | 0.9854 | 0.0100 |
| Hs 578T | GW7647 | 72 | inf | 0.8977 | -0.0280 | 0.0000 | 1.0000 | 0.0100 |
| Hs 578T | HBX19818 | 72 | 11.9910919139 | -0.5368 | 0.2444 | 15.5278 | -0.5808 | 2.9824 |
| Hs 578T | HBX 41108 | 72 | 0.833261758014 | -0.3648 | 0.6116 | 1.1826 | -0.3412 | 1.4860 |