Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1328 | HY-17542 | 72 | inf | 0.7180 | 0.0045 | 0.0000 | 0.9630 | 0.0100 |
| PDX1328 | HY-50736 | 72 | 0.0450637341098 | -0.6880 | 1.3911 | 0.0825 | -0.8217 | 1.6084 |
| PDX1328 | HY-50737A | 72 | 0.2644727784 | -0.8890 | 1.0078 | 0.4995 | -0.8567 | 1.5697 |
| PDX1328 | IU1 | 72 | inf | 0.6034 | 0.0522 | 0.0000 | 0.9321 | 0.0100 |
| PDX1328 | LDN57444 | 72 | 29.0838578196 | 0.1664 | 0.1568 | 64.9414 | -1.0000 | 1.3676 |
| PDX1328 | MI-2 | 72 | 5.25760821785 | -0.9161 | 0.4330 | 6.4858 | -0.9284 | 5.0000 |
| PDX1328 | ML-323 | 72 | inf | 0.7525 | 0.0851 | 0.0000 | 0.9071 | 0.0100 |
| PDX1328 | Pevonedistat | 72 | inf | -0.7089 | -0.4505 | 0.0000 | 1.0000 | 0.0100 |
| PDX1328 | PB49673382 | 72 | 15.1116355121 | -0.3801 | 0.1383 | 38.8250 | -1.0000 | 1.1643 |
| PDX1328 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9911 | 0.0513 | 0.0000 | 0.9569 | 0.0100 |
| PDX1328 | SB1-F-21 | 72 | 0.844936773852 | -0.9869 | 0.7625 | 1.8713 | -1.0000 | 1.3817 |
| PDX1328 | SB1-F-22 | 72 | inf | 1.0347 | -0.2404 | 0.0000 | 1.0000 | 0.0100 |
| PDX1328 | SJB2-043 | 72 | 0.283039978056 | -0.9550 | 0.9369 | 0.3776 | -0.9607 | 3.7191 |
| PDX1328 | SJB3-019A | 72 | 0.117013699533 | -0.9745 | 1.3027 | 0.1897 | -0.9715 | 2.2348 |
| PDX1328 | STK547622 | 72 | inf | 0.8225 | 0.0964 | 0.0000 | 0.9216 | 0.0100 |
| PDX1328 | Vialinin A | 72 | 6.5234902309 | -0.8259 | 0.3553 | 12.0354 | -0.9870 | 1.7796 |
| PDX1328 | Degrasyn | 72 | 2.23838869532 | -0.9056 | 0.6219 | 3.3568 | -0.9207 | 2.5770 |
| PDX1328 | Sepantronium | 72 | 0.0218983386219 | -0.9670 | 1.5930 | 0.0347 | -0.5708 | 1.6579 |
| PDX1328 | b-AP15 | 72 | 0.183369061603 | -0.9168 | 1.1450 | 0.2761 | -0.8858 | 2.4900 |
| PDX1328 | Doxycycline | 72 | inf | 1.0834 | 0.0387 | 0.0000 | 0.9720 | 0.0100 |
| PDX1328 | Mitoxantrone | 72 | 0.0227860417414 | -0.9642 | 1.3672 | 0.1228 | -1.0000 | 0.6522 |
| PDX1328 | P22077 | 72 | 8.67568163015 | -0.9510 | 0.3247 | 12.1205 | -0.9858 | 3.2572 |
| PDX1328 | Pimozide | 72 | 9.51211170773 | -0.8995 | 0.2585 | 11.6946 | -0.9045 | 5.0000 |
| PDX1328 | Spautin-1 | 72 | 43.5833222905 | 0.4636 | 0.1399 | 310.0635 | -1.0000 | 0.5599 |
| PDX1328 | Trifluoperazine | 72 | 10.4012800704 | -0.9795 | 0.3652 | 12.9427 | -0.9916 | 5.0000 |