Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| PDX1258 | Pevonedistat | 72 | 0.270220542659 | -0.3092 | 0.7119 | 0.4435 | -0.2984 | 0.9444 |
| PDX1258 | PB49673382 | 72 | 5.45211284753 | 0.1759 | 0.2476 | 5.0473 | 0.1600 | 5.0000 |
| PDX1258 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0981 | 0.0141 | 0.0000 | 0.9940 | 0.0100 |
| PDX1258 | SB1-F-21 | 72 | 1.05674741818 | -0.7071 | 0.6672 | 1.5380 | -0.6927 | 2.3164 |
| PDX1258 | SB1-F-22 | 72 | 141.822011334 | 0.6791 | 0.0519 | 862.0159 | -1.0000 | 0.6088 |
| PDX1258 | SJB2-043 | 72 | 0.885786050221 | -0.4791 | 0.4693 | 1.0043 | -0.4368 | 5.0000 |
| PDX1258 | SJB3-019A | 72 | 0.465986460631 | -0.5823 | 0.7715 | 0.5616 | -0.5695 | 4.0736 |
| PDX1258 | STK547622 | 72 | inf | 0.9659 | 0.0292 | 0.0000 | 0.9845 | 0.0100 |
| PDX1258 | Vialinin A | 72 | 13.4082942872 | -0.2326 | 0.1129 | 16.1961 | -0.2877 | 2.4064 |
| PDX1258 | Degrasyn | 72 | 2.04245876356 | -0.5884 | 0.5464 | 2.6223 | -0.5503 | 2.9704 |
| PDX1258 | Sepantronium | 72 | 0.0944990954 | -0.5758 | 0.9903 | 0.1955 | -0.5482 | 1.0184 |
| PDX1258 | b-AP15 | 72 | 0.186230489102 | -0.6381 | 0.9074 | 0.3277 | -0.5748 | 1.3539 |
| PDX1258 | Doxycycline | 72 | inf | 0.6311 | 0.1246 | 0.0000 | 0.8362 | 0.0100 |
| PDX1258 | Mitoxantrone | 72 | 0.007407644519 | -0.6933 | 1.1643 | 0.2222 | -1.0000 | 0.3230 |
| PDX1258 | P22077 | 72 | 3.1997536366 | -0.5772 | 0.4517 | 4.5424 | -0.5888 | 2.2210 |
| PDX1258 | Pimozide | 72 | 5.06894491311 | -0.3597 | 0.3871 | 19.1221 | -1.0000 | 0.8274 |
| PDX1258 | Spautin-1 | 72 | inf | 0.6270 | 0.1154 | 7.2635 | 0.5872 | 0.8220 |
| PDX1258 | Trifluoperazine | 72 | 9.06336153073 | -0.6331 | 0.3343 | 13.1356 | -0.7329 | 2.4320 |
| PDX1258 | z-VAE(OMe)-fmk | 72 | inf | 0.9262 | 0.0692 | 0.0000 | 0.9516 | 0.0100 |
| PDX1328 | 1247825-37-1 | 72 | 22.1349466658 | -0.4424 | 0.1065 | 25.3891 | -0.4927 | 5.0000 |
| PDX1328 | USP7-IN-1 | 72 | inf | 0.9243 | 0.1135 | 0.0000 | 0.9000 | 0.0100 |
| PDX1328 | GW7647 | 72 | inf | 0.8376 | -0.0784 | 0.0000 | 1.0000 | 0.0100 |
| PDX1328 | HBX19818 | 72 | 13.6607133025 | -0.9490 | 0.3096 | 19.8613 | -1.0000 | 2.9355 |
| PDX1328 | HBX 41108 | 72 | 0.252282958678 | -0.8598 | 0.9493 | 0.8725 | -0.9529 | 0.8597 |
| PDX1328 | HY-17541A | 72 | 6.04754155289 | -0.9724 | 0.3564 | 13.0481 | -1.0000 | 1.4286 |