Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1954 | SJB3-019A | 72 | 0.514424957783 | -0.7154 | 0.8423 | 0.6815 | -0.7101 | 3.1432 |
| HCC1954 | STK547622 | 72 | inf | 0.8996 | 0.0165 | 0.0000 | 0.9826 | 0.0100 |
| HCC1954 | Vialinin A | 72 | 5.65032712603 | -0.4035 | 0.2903 | 9.0380 | -0.4804 | 1.4335 |
| HCC1954 | Degrasyn | 72 | 3.28733078255 | -0.6866 | 0.5156 | 3.9070 | -0.6857 | 5.0000 |
| HCC1954 | Sepantronium | 72 | 0.0107560548807 | -0.7271 | 1.4585 | 0.0156 | -0.4591 | 1.7448 |
| HCC1954 | b-AP15 | 72 | 0.0709214214205 | -0.7172 | 1.2064 | 0.1119 | -0.6936 | 1.9069 |
| HCC1954 | Doxycycline | 72 | 23.9368215941 | 0.0566 | 0.0431 | 24.0739 | -0.0145 | 5.0000 |
| HCC1954 | Mitoxantrone | 72 | 0.0141773373515 | -0.6799 | 1.1790 | 0.1017 | -0.7312 | 0.4574 |
| HCC1954 | P22077 | 72 | 3.99414837065 | -0.8173 | 0.3966 | 8.7096 | -0.9912 | 1.4017 |
| HCC1954 | Pimozide | 72 | 10.6179238171 | -0.3320 | 0.2520 | 12.4471 | -0.3629 | 3.4336 |
| HCC1954 | Spautin-1 | 72 | 6.85692752046 | 0.2805 | 0.2576 | 3.7201 | 0.1916 | 0.7903 |
| HCC1954 | Trifluoperazine | 72 | 10.7631304172 | -0.7744 | 0.2931 | 13.0385 | -0.7772 | 4.8899 |
| HCC1954 | z-VAE(OMe)-fmk | 72 | inf | 1.0513 | 0.0385 | 0.0000 | 0.9751 | 0.0100 |
| HCC202 | 1247825-37-1 | 72 | 8.82600510672 | -0.3858 | 0.1854 | 10.8343 | -0.3618 | 2.6557 |
| HCC202 | USP7-IN-1 | 72 | inf | 0.8501 | -0.0200 | 0.0000 | 1.0000 | 0.0100 |
| HCC202 | GW7647 | 72 | inf | 0.8031 | -0.0688 | 0.0000 | 1.0000 | 0.0100 |
| HCC202 | HBX19818 | 72 | 15.8528818617 | -0.3562 | 0.1986 | 34.9884 | -1.0000 | 1.3877 |
| HCC202 | HBX 41108 | 72 | 0.683600987561 | -0.5099 | 0.6221 | 3.3736 | -0.8219 | 0.6090 |
| HCC202 | HY-17541A | 72 | 7.97410131961 | -0.7625 | 0.4142 | 15.8638 | -0.9318 | 1.5296 |
| HCC202 | HY-17542 | 72 | 68.7359336666 | 0.6087 | 0.0718 | 43.2417 | 0.3314 | 2.3458 |
| HCC202 | HY-50736 | 72 | 0.0428061682624 | -0.4761 | 1.2531 | 0.0686 | -0.5861 | 1.6431 |
| HCC202 | HY-50737A | 72 | 0.256783423743 | -0.6392 | 0.8916 | 0.4419 | -0.6154 | 1.4780 |
| HCC202 | IU1 | 72 | inf | 0.7641 | -0.0242 | 0.0000 | 0.9954 | 0.0100 |
| HCC202 | LDN57444 | 72 | 35.5631753073 | 0.1261 | 0.0350 | 36.2274 | -0.0485 | 5.0000 |
| HCC202 | MI-2 | 72 | 1.05934529798 | -0.7616 | 0.7515 | 1.3228 | -0.7564 | 4.1491 |