Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| BT-20 | Doxycycline | 72 | inf | 0.5650 | 0.0355 | 0.0000 | 0.9177 | 0.0100 |
| BT-20 | Mitoxantrone | 72 | 0.00114283548045 | -0.8192 | 1.3912 | 0.0267 | -0.9144 | 0.3300 |
| BT-20 | P22077 | 72 | 5.68690045385 | -0.8029 | 0.3725 | 7.9927 | -0.8136 | 2.8380 |
| BT-20 | Pimozide | 72 | 10.6841586302 | -0.7844 | 0.2746 | 12.9223 | -0.7941 | 5.0000 |
| BT-20 | Spautin-1 | 72 | inf | 0.5940 | 0.0846 | 8.5501 | 0.5911 | 1.1552 |
| BT-20 | Trifluoperazine | 72 | 12.3504591925 | -0.7940 | 0.2886 | 14.9777 | -0.8115 | 5.0000 |
| BT-20 | z-VAE(OMe)-fmk | 72 | inf | 0.9762 | 0.0198 | 0.0000 | 0.9890 | 0.0100 |
| BT-549 | 1247825-37-1 | 72 | 13.5700541273 | -0.0465 | 0.1614 | 13.9726 | -0.0577 | 3.7355 |
| BT-549 | USP7-IN-1 | 72 | 94.531181628 | 0.8209 | 0.0177 | 166.1357 | -1.0000 | 1.9483 |
| BT-549 | GW7647 | 72 | 38.3765494331 | 0.2776 | 0.0356 | 35.9668 | 0.1385 | 5.0000 |
| BT-549 | HBX19818 | 72 | 28.4956034945 | -0.3396 | 0.1206 | 40.2238 | -1.0000 | 3.1871 |
| BT-549 | HBX 41108 | 72 | 0.419436290406 | -0.3090 | 0.6569 | 0.7538 | -0.3407 | 0.8863 |
| BT-549 | HY-17541A | 72 | 16.8403527969 | -0.5863 | 0.1928 | 28.1688 | -1.0000 | 2.1356 |
| BT-549 | HY-17542 | 72 | 121.066157283 | 0.9061 | 0.0081 | 95.3962 | 0.2549 | 2.9917 |
| BT-549 | HY-50736 | 72 | 0.0483582820394 | -0.3009 | 1.0550 | 0.0658 | -0.3461 | 1.7080 |
| BT-549 | HY-50737A | 72 | 0.248578831213 | -0.3321 | 0.8077 | 0.3314 | -0.3617 | 1.8923 |
| BT-549 | IU1 | 72 | inf | 0.9301 | 0.0193 | 16.1731 | 0.9293 | 3.6587 |
| BT-549 | LDN57444 | 72 | 26.3227602476 | -0.0929 | 0.1129 | 39.5696 | -0.7414 | 2.2310 |
| BT-549 | MI-2 | 72 | 0.571326549598 | -0.4518 | 0.7504 | 0.6753 | -0.4619 | 3.9147 |
| BT-549 | ML-323 | 72 | 74.3999913582 | 0.5763 | 0.0892 | 442.2433 | -1.0000 | 0.6164 |
| BT-549 | Pevonedistat | 72 | 0.209348073627 | -0.2452 | 0.7301 | 0.2903 | -0.2281 | 1.1500 |
| BT-549 | PB49673382 | 72 | 4.76901821965 | -0.0004 | 0.2990 | 4.7981 | -0.0079 | 2.5928 |
| BT-549 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9516 | 0.0187 | 0.0000 | 0.9793 | 0.0100 |
| BT-549 | SB1-F-21 | 72 | 0.760785207837 | -0.2236 | 0.5516 | 1.0377 | -0.2180 | 1.1656 |
| BT-549 | SB1-F-22 | 72 | inf | 0.8206 | 0.0279 | 14.6898 | 0.8108 | 2.3064 |