Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| CAMA-1 | MI-2 | 72 | 0.530718147156 | -0.4633 | 0.7592 | 0.6284 | -0.4414 | 3.7466 |
| CAMA-1 | ML-323 | 72 | 28.720597579 | 0.2218 | 0.1069 | 83.5494 | -1.0000 | 1.0288 |
| CAMA-1 | Pevonedistat | 72 | 0.0450559209474 | -0.1660 | 0.9043 | 0.0502 | -0.1172 | 1.9572 |
| CAMA-1 | PB49673382 | 72 | 3.4845103029 | -0.0579 | 0.3546 | 3.6236 | -0.0592 | 2.8598 |
| CAMA-1 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9375 | 0.0403 | 0.0000 | 0.9497 | 0.0100 |
| CAMA-1 | SB1-F-21 | 72 | 0.356288555928 | -0.6495 | 0.7890 | 0.7680 | -0.6356 | 1.0680 |
| CAMA-1 | SB1-F-22 | 72 | 43.6088606735 | 0.4408 | 0.0565 | 156.5267 | -1.0000 | 0.8597 |
| CAMA-1 | SJB2-043 | 72 | 0.372483737956 | -0.4977 | 0.7091 | 0.4732 | -0.5024 | 2.9069 |
| CAMA-1 | SJB3-019A | 72 | 0.282886176656 | -0.5665 | 0.8783 | 0.3283 | -0.4948 | 4.6169 |
| CAMA-1 | STK547622 | 72 | inf | 0.8258 | 0.0467 | 0.0000 | 0.9496 | 0.0100 |
| CAMA-1 | Vialinin A | 72 | 8.96202630369 | -0.5255 | 0.2577 | 13.2114 | -0.6248 | 2.0890 |
| CAMA-1 | Degrasyn | 72 | 1.91400918301 | -0.6784 | 0.6041 | 2.6284 | -0.6527 | 2.6337 |
| CAMA-1 | Sepantronium | 72 | 0.00492479486482 | -0.5726 | 1.4926 | 0.0065 | -0.5275 | 2.5831 |
| CAMA-1 | b-AP15 | 72 | 0.125560211136 | -0.5018 | 1.0206 | 0.1671 | -0.5285 | 2.5236 |
| CAMA-1 | Doxycycline | 72 | 20.1165363681 | -0.1002 | 0.1702 | 44.6977 | -1.0000 | 1.3761 |
| CAMA-1 | Mitoxantrone | 72 | 0.0062993374498 | -0.8126 | 1.3228 | 0.0295 | -0.6695 | 0.5504 |
| CAMA-1 | P22077 | 72 | 11.4553998621 | -0.6434 | 0.2586 | 15.3149 | -0.6964 | 3.0047 |
| CAMA-1 | Pimozide | 72 | 10.5638318882 | -0.6260 | 0.3203 | 12.3722 | -0.6018 | 5.0000 |
| CAMA-1 | Spautin-1 | 72 | 8.38966554919 | 0.1933 | 0.2334 | 6.6491 | 0.1026 | 0.9877 |
| CAMA-1 | Trifluoperazine | 72 | 8.45406954344 | -0.6457 | 0.3334 | 11.8787 | -0.7033 | 2.5823 |
| CAMA-1 | z-VAE(OMe)-fmk | 72 | inf | 0.9619 | 0.0262 | 0.0000 | 0.9726 | 0.0100 |
| HCC1419 | 1247825-37-1 | 72 | 11.9633348293 | -0.2267 | 0.1675 | 13.1469 | -0.2174 | 3.8271 |
| HCC1419 | USP7-IN-1 | 72 | 44.7550079567 | 0.4088 | 0.0472 | 76.1826 | -1.0000 | 2.0653 |
| HCC1419 | GW7647 | 72 | 39.4857944397 | -0.0439 | 0.0074 | 49.1887 | -1.0000 | 5.0000 |
| HCC1419 | HBX19818 | 72 | 18.9629402973 | -0.3826 | 0.1144 | 33.7889 | -1.0000 | 1.9019 |