Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | STK547622 | 72 | inf | 1.0471 | -0.1279 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-361 | Vialinin A | 72 | 7.75271686789 | -0.4045 | 0.2275 | 8.9559 | -0.3189 | 3.4198 |
| MDA-MB-361 | Degrasyn | 72 | 4.30347364647 | -0.6620 | 0.3590 | 5.1207 | -0.6042 | 4.5568 |
| MDA-MB-361 | Sepantronium | 72 | 1.5586359565 | -0.7783 | 0.5362 | 2.4507 | -0.7241 | 1.9784 |
| MDA-MB-361 | b-AP15 | 72 | 0.109447404861 | -0.6928 | 1.0525 | 0.1830 | -0.6219 | 1.5720 |
| MDA-MB-361 | Doxycycline | 72 | inf | 0.9696 | 0.0534 | 0.0000 | 0.9201 | 0.0100 |
| MDA-MB-361 | Mitoxantrone | 72 | 0.00180293182659 | -0.9488 | 1.4412 | 0.0357 | -1.0000 | 0.3678 |
| MDA-MB-361 | P22077 | 72 | 4.13836928662 | -0.7524 | 0.4217 | 7.0578 | -0.8139 | 1.8098 |
| MDA-MB-361 | Pimozide | 72 | 12.9023293957 | -0.6485 | 0.2470 | 22.5246 | -1.0000 | 1.9717 |
| MDA-MB-361 | Spautin-1 | 72 | 6.94135435106 | -0.1974 | 0.2123 | 7.5347 | -0.1634 | 3.4474 |
| MDA-MB-361 | Trifluoperazine | 72 | 9.45447519759 | -0.7673 | 0.3443 | 11.3498 | -0.7466 | 5.0000 |
| MDA-MB-361 | z-VAE(OMe)-fmk | 72 | inf | 0.9096 | 0.0284 | 0.0000 | 0.9738 | 0.0100 |
| PDX1258 | 1247825-37-1 | 72 | 13.2811411655 | 0.1210 | 0.0958 | 12.5137 | 0.1287 | 5.0000 |
| PDX1258 | USP7-IN-1 | 72 | inf | 0.8007 | 0.0688 | 0.0000 | 0.9245 | 0.0100 |
| PDX1258 | GW7647 | 72 | inf | 1.0702 | -0.0651 | 0.0000 | 1.0000 | 0.0100 |
| PDX1258 | HBX19818 | 72 | 26.8677504629 | -0.4248 | 0.1477 | 37.8431 | -1.0000 | 3.2074 |
| PDX1258 | HBX 41108 | 72 | 0.19093097022 | -0.5289 | 0.8289 | 0.5067 | -0.5544 | 0.7646 |
| PDX1258 | HY-17541A | 72 | 4.88569792161 | -0.6381 | 0.3717 | 13.5459 | -1.0000 | 1.0773 |
| PDX1258 | HY-17542 | 72 | inf | 0.8526 | 0.0249 | 0.0000 | 0.9656 | 0.0100 |
| PDX1258 | HY-50736 | 72 | 0.0087703068144 | -0.3555 | 1.4216 | 0.0121 | -0.3791 | 1.7398 |
| PDX1258 | HY-50737A | 72 | 0.0413916873909 | -0.6402 | 1.2194 | 0.0709 | -0.5806 | 1.4319 |
| PDX1258 | IU1 | 72 | inf | 0.7739 | 0.0478 | 9.3467 | 0.8104 | 5.0000 |
| PDX1258 | LDN57444 | 72 | 3.14059414409 | 0.4353 | 0.2988 | 0.2800 | 0.4861 | 1.4815 |
| PDX1258 | MI-2 | 72 | 2.05087982373 | -0.6053 | 0.5515 | 3.4388 | -0.6650 | 1.6366 |
| PDX1258 | ML-323 | 72 | inf | 0.7683 | 0.0266 | 0.0000 | 0.9660 | 0.0100 |