Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | P22077 | 72 | 14.6624018854 | -0.4168 | 0.1929 | 17.8309 | -0.4659 | 3.3658 |
| MDA-MB-231 | Pimozide | 72 | 10.4602330179 | -0.3159 | 0.2543 | 23.8689 | -0.9171 | 1.2628 |
| MDA-MB-231 | Spautin-1 | 72 | inf | 0.8635 | 0.0004 | 0.0000 | 0.9855 | 0.0100 |
| MDA-MB-231 | Trifluoperazine | 72 | 10.5680484493 | -0.5359 | 0.3729 | 12.2172 | -0.5163 | 4.8917 |
| MDA-MB-231 | z-VAE(OMe)-fmk | 72 | inf | 0.9382 | 0.0024 | 0.0000 | 0.9922 | 0.0100 |
| MDA-MB-361 | 1247825-37-1 | 72 | 13.2255127818 | -0.4648 | 0.1648 | 21.0813 | -0.7304 | 1.9314 |
| MDA-MB-361 | USP7-IN-1 | 72 | inf | 0.4344 | 0.0785 | 0.0000 | 0.8766 | 0.0100 |
| MDA-MB-361 | GW7647 | 72 | inf | 0.9669 | -0.0010 | 0.0000 | 0.9993 | 0.0100 |
| MDA-MB-361 | HBX19818 | 72 | 20.1726714877 | -0.3872 | 0.0630 | 34.0507 | -1.0000 | 2.0985 |
| MDA-MB-361 | HBX 41108 | 72 | 2.39879103002 | -0.6248 | 0.4563 | 9.0063 | -1.0000 | 0.8304 |
| MDA-MB-361 | HY-17541A | 72 | 8.08778635864 | -0.8457 | 0.3036 | 20.0570 | -1.0000 | 1.2096 |
| MDA-MB-361 | HY-17542 | 72 | inf | 0.8632 | -0.0548 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-361 | HY-50736 | 72 | 0.608322194455 | -0.4431 | 0.6883 | 0.9920 | -0.5060 | 1.4296 |
| MDA-MB-361 | HY-50737A | 72 | 2.34765001883 | -0.5291 | 0.4893 | 3.2880 | -0.5082 | 2.0817 |
| MDA-MB-361 | IU1 | 72 | inf | 0.7838 | -0.0464 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-361 | LDN57444 | 72 | inf | 0.7028 | 0.0394 | 0.0000 | 0.9351 | 0.0100 |
| MDA-MB-361 | MI-2 | 72 | 3.80487472111 | -0.7848 | 0.4779 | 4.6826 | -0.7574 | 4.4428 |
| MDA-MB-361 | ML-323 | 72 | 40.0818936622 | 0.3655 | 0.0465 | 56.4514 | -0.4200 | 1.7805 |
| MDA-MB-361 | Pevonedistat | 72 | 0.105133263812 | -0.3279 | 0.8618 | 0.1270 | -0.2800 | 2.3487 |
| MDA-MB-361 | PB49673382 | 72 | 9.80262963264 | -0.2517 | 0.1526 | 10.3320 | -0.1504 | 5.0000 |
| MDA-MB-361 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 1.0999 | 0.0175 | 0.0000 | 1.0000 | 0.0100 |
| MDA-MB-361 | SB1-F-21 | 72 | 0.683787272085 | -0.7860 | 0.7684 | 0.8135 | -0.6777 | 4.9337 |
| MDA-MB-361 | SB1-F-22 | 72 | 89.7808679432 | 0.3965 | 0.0864 | 5.1416 | 0.4877 | 1.2948 |
| MDA-MB-361 | SJB2-043 | 72 | 1.59047305005 | -0.2559 | 0.3538 | 1.7814 | -0.2365 | 3.4159 |
| MDA-MB-361 | SJB3-019A | 72 | 0.668312775117 | -0.7320 | 0.8218 | 0.7953 | -0.6795 | 4.9328 |