Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1937 | USP7-IN-1 | 72 | 65.8738738326 | 0.8119 | -0.0032 | 83.7971 | -0.9000 | 4.2784 |
| HCC1937 | GW7647 | 72 | inf | 0.8246 | -0.0146 | 0.0000 | 0.9883 | 0.0100 |
| HCC1937 | HBX19818 | 72 | 26.0037277737 | -0.0518 | 0.1251 | 48.2744 | -1.0000 | 1.7758 |
| HCC1937 | HBX 41108 | 72 | 0.197216521638 | -0.4641 | 0.7356 | 1.4877 | -0.7065 | 0.4359 |
| HCC1937 | HY-17541A | 72 | 8.60246999082 | -0.5555 | 0.2722 | 17.8989 | -0.9818 | 1.4828 |
| HCC1937 | HY-17542 | 72 | inf | 0.9422 | -0.0439 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | HY-50736 | 72 | 0.0175748900813 | -0.4737 | 1.2706 | 0.0315 | -0.5040 | 1.1960 |
| HCC1937 | HY-50737A | 72 | 0.0985106934226 | -0.4932 | 0.9863 | 0.1784 | -0.5076 | 1.1795 |
| HCC1937 | IU1 | 72 | inf | 0.8662 | 0.0085 | 0.0000 | 0.9831 | 0.0100 |
| HCC1937 | LDN57444 | 72 | 17.7638889324 | 0.2980 | 0.1506 | 9.8052 | 0.2523 | 1.1822 |
| HCC1937 | MI-2 | 72 | 1.5435411034 | -0.5588 | 0.5652 | 2.1666 | -0.5722 | 2.2498 |
| HCC1937 | ML-323 | 72 | 86.9696327252 | 0.6194 | 0.0517 | 375.1322 | -0.9832 | 0.7439 |
| HCC1937 | Pevonedistat | 72 | 0.0855702491458 | -0.1081 | 0.7701 | 0.0915 | -0.0540 | 1.5279 |
| HCC1937 | PB49673382 | 72 | 7.51602525958 | 0.2509 | 0.2135 | 5.4225 | 0.2446 | 2.0574 |
| HCC1937 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9970 | -0.0035 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | SB1-F-21 | 72 | 1.65332825592 | -0.6548 | 0.5638 | 2.4886 | -0.6666 | 2.0718 |
| HCC1937 | SB1-F-22 | 72 | inf | 0.7329 | 0.0511 | 23.6262 | 0.6973 | 2.7086 |
| HCC1937 | SJB2-043 | 72 | 0.396049351375 | -0.5581 | 0.6542 | 0.6443 | -0.5754 | 1.5740 |
| HCC1937 | SJB3-019A | 72 | 0.22094135853 | -0.6386 | 0.9798 | 0.3369 | -0.6446 | 1.9637 |
| HCC1937 | STK547622 | 72 | inf | 1.0316 | -0.0512 | 0.0000 | 1.0000 | 0.0100 |
| HCC1937 | Vialinin A | 72 | 8.32590505669 | -0.2754 | 0.2500 | 10.0381 | -0.2833 | 2.4000 |
| HCC1937 | Degrasyn | 72 | 3.23543546484 | -0.4694 | 0.4319 | 3.6822 | -0.4546 | 5.0000 |
| HCC1937 | Sepantronium | 72 | 0.0274217558915 | -0.5570 | 1.2238 | 0.0525 | -0.5494 | 1.1409 |
| HCC1937 | b-AP15 | 72 | 0.169991331199 | -0.5230 | 0.9178 | 0.2473 | -0.4991 | 1.8473 |
| HCC1937 | Doxycycline | 72 | 38.7534725906 | 0.3254 | 0.0415 | 55.5476 | -0.4988 | 1.9220 |