Breast Cancer Deubiquitinating Enzyme (DUB) Inhibitor Profiling: Fixed-cell GR measures of 21 breast cell lines to 32 small molecule perturbagens. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20351)
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| Cell | Small Molecule | Treatment Duration | GR50 | GRmax | GR_AOC | GEC50 | GRinf | hGR |
|---|---|---|---|---|---|---|---|---|
| HCC1806 | HY-50737A | 72 | 11.8311020156 | -0.2747 | 0.2199 | 12.8932 | -0.2685 | 5.0000 |
| HCC1806 | IU1 | 72 | 116.251943958 | 0.8831 | 0.0051 | 197.1530 | -0.9493 | 2.0147 |
| HCC1806 | LDN57444 | 72 | 20.8632565992 | -0.2951 | 0.1515 | 37.1169 | -1.0000 | 1.9070 |
| HCC1806 | MI-2 | 72 | 3.9059429509 | -0.5803 | 0.4525 | 4.7751 | -0.5651 | 3.7640 |
| HCC1806 | ML-323 | 72 | 51.7025090437 | 0.5104 | 0.0851 | 100.5354 | -0.3756 | 0.8426 |
| HCC1806 | Pevonedistat | 72 | 0.0335529495438 | -0.2883 | 1.0267 | 0.0419 | -0.2494 | 1.8239 |
| HCC1806 | PB49673382 | 72 | 6.71137786447 | 0.1357 | 0.2326 | 5.6599 | 0.1234 | 1.6630 |
| HCC1806 | 5-(4-fluorophenyl)-3-hydroxy-4-(5-methyl-2-furoyl)-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one | 72 | inf | 0.9460 | 0.0193 | 0.0000 | 0.9791 | 0.0100 |
| HCC1806 | SB1-F-21 | 72 | 2.13484035995 | -0.5380 | 0.5257 | 3.0789 | -0.5502 | 2.0265 |
| HCC1806 | SB1-F-22 | 72 | inf | 0.6439 | 0.0344 | 17.7713 | 0.6398 | 4.3131 |
| HCC1806 | SJB2-043 | 72 | 4.05064367394 | -0.1302 | 0.2617 | 4.3188 | -0.1361 | 3.7560 |
| HCC1806 | SJB3-019A | 72 | 1.08819234449 | -0.1983 | 0.5270 | 1.1814 | -0.1960 | 4.0231 |
| HCC1806 | STK547622 | 72 | inf | 0.9848 | 0.0194 | 0.0000 | 0.9841 | 0.0100 |
| HCC1806 | Vialinin A | 72 | 10.1468204153 | -0.3590 | 0.2361 | 11.8590 | -0.3766 | 3.6003 |
| HCC1806 | Degrasyn | 72 | 2.75238625089 | -0.3101 | 0.4592 | 3.0534 | -0.3402 | 5.0000 |
| HCC1806 | Sepantronium | 72 | 0.0194330717839 | -0.2281 | 1.0647 | 0.0221 | -0.1914 | 2.4836 |
| HCC1806 | b-AP15 | 72 | 0.166759705504 | -0.5022 | 0.8776 | 0.2119 | -0.3656 | 2.2899 |
| HCC1806 | Doxycycline | 72 | 17.2474618301 | -0.1768 | 0.1626 | 21.2744 | -0.3287 | 2.4080 |
| HCC1806 | Mitoxantrone | 72 | 0.0444174670492 | -0.2704 | 0.9420 | 0.0607 | -0.2125 | 1.1318 |
| HCC1806 | P22077 | 72 | 10.1999122294 | -0.4514 | 0.2415 | 13.5370 | -0.5064 | 2.4715 |
| HCC1806 | Pimozide | 72 | 11.3348298234 | -0.4227 | 0.2230 | 12.8256 | -0.4274 | 5.0000 |
| HCC1806 | Spautin-1 | 72 | inf | 0.7327 | 0.0879 | 3.6771 | 0.7379 | 1.4312 |
| HCC1806 | Trifluoperazine | 72 | 10.9947833372 | -0.4718 | 0.2306 | 13.1239 | -0.4829 | 3.8183 |
| HCC1806 | z-VAE(OMe)-fmk | 72 | inf | 0.9581 | 0.0231 | 0.0000 | 0.9783 | 0.0100 |
| HCC1937 | 1247825-37-1 | 72 | 13.156649451 | 0.0110 | 0.1377 | 13.6093 | -0.0392 | 2.2330 |