Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1500 Trametinib
MEK
MAPK/nRTK
0.14491
 0.3439 0.2190 0.0408 0.9370
0.049167
0.9913
HCC1500 Saracatinib
SRC
MAPK/nRTK
0.25821
 -0.1966 0.4364 0.0562 0.5724
0.7598
0.97739
HCC1500 ABT-737
Bcl2/XL
Misc
0.0085142
 -0.7359 1.1288 0.3716 0.9283
0.022222
0.99554
HCC1500 Vorinostat
HDAC
Misc
0.95606
 -0.5960 0.3173 0.1165 1.0951
2.5286
0.99617
HCC1500 Luminespib
HSP90
Misc
0.0084603
 -0.2243 0.5973 0.1676 5.0000
0.009043
0.99641
HCC1500 A-1210477
Mcl-1
Misc
Inf
 0.8719 -0.0368 0.0081 0.0000
Inf
0.32761
HCC1500 Olaparib
PARP
Misc
6.3506
 0.2744 0.0985 0.0084 1.0887
17.4212
0.94589
HCC1500 Bleomycin
Radiation
Misc
2.3381
 0.1740 0.1688 -0.0166 1.0174
2.4596
0.98358
HCC1500 Ipatasertib
AKT
PI3K/mTOR
Inf
 1.0500 -0.0314 -0.0045 0.0000
Inf
-1.0541
HCC1500 Alpelisib
PI3Ka
PI3K/mTOR
12.7881
 0.5807 0.0302 0.0118 1.1251
18.7215
0.91512
HCC1500 Taselisib
PI3Ka, g, d
PI3K/mTOR
1.8598
 -0.2328 0.2303 0.0444 0.8754
6.5237
0.97328
HCC1500 TGX221
PI3Kb
PI3K/mTOR
10.1303
 0.5035 0.0860 0.0066 0.8370
24.4491
0.82467
HCC1500 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0017504
 -0.4967 0.9053 0.2022 1.3577
0.0027734
0.99119
HCC1500 Everolimus
mTOR1
PI3K/mTOR
Inf
 -0.3096 1.2601 0.2328 0.0000
Inf
0.51907
HCC1500 INK-128
mTORC1/2
PI3K/mTOR
0.00078427
 -0.4693 1.2309 0.2717 1.2780
0.0013303
0.99127
HCC1500 PF-4708671
p70S6K
PI3K/mTOR
1.671
 0.0495 0.1975 0.0284 1.0444
2.0815
0.99138
HCC1500 Buparlisib
pan PI3K
PI3K/mTOR
0.20179
 -0.5459 0.5351 0.1146 0.8962
0.51424
0.99364
HCC1500 Pictilisib
pan PI3K
PI3K/mTOR
2.3061
 -0.1317 0.2108 0.0313 0.8635
8.2307
0.96692
HCC1500 Ceritinib
ALK
RTK
1.4068
 -0.9535 0.2988 0.1206 1.5745
2.8266
0.97255
HCC1500 Neratinib
EGFR/HER2
RTK
0.7842
 -0.2872 0.1852 0.0616 1.1924
1.9705
0.99465
HCC1500 Tivantinib
MET
RTK
0.11523
 -0.3304 0.5109 0.1445 1.9906
0.13024
0.97326
HCC1500 Cediranib
VEGFR/cKIT
RTK
3.8594
 -0.8084 0.1304 0.0735 3.4916
5.2864
0.99235
HCC1500 Cabozantinib
VEGFR2/MET
RTK
4.6683
 0.1837 0.0599 0.0128 4.9992
4.2912
0.97044
HCC1937 Abemaciclib
CDK4/6
Cell cycle
4.8534
 0.3020 0.1062 0.0050 0.9638
6.1622
0.98334
HCC1937 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0500 -0.0406 -0.0017 0.0000
Inf
-4.6521