Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1419 Alpelisib
PI3Ka
PI3K/mTOR
0.66882
 -0.0020 0.3558 0.0157 0.3922
11.0132
0.94051
HCC1419 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0091784
 -0.4046 0.8523 0.0945 0.5809
0.022714
0.98223
HCC1419 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7941 -0.0049 0.0002 5.0000
3.889
0.79312
HCC1419 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0054867
 -0.3722 0.6345 0.0796 0.8272
0.0093689
0.98036
HCC1419 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.1803 0.7242 0.0249 0.0000
Inf
0.37602
HCC1419 INK-128
mTORC1/2
PI3K/mTOR
0.0047477
 -0.1472 0.7635 0.0603 1.3112
0.0056144
0.99448
HCC1419 PF-4708671
p70S6K
PI3K/mTOR
5.2795
 0.3488 0.1117 -0.0019 1.0898
4.6502
0.97858
HCC1419 Buparlisib
pan PI3K
PI3K/mTOR
0.39623
 -0.4961 0.4499 0.0745 0.8204
1.2651
0.99188
HCC1419 Pictilisib
pan PI3K
PI3K/mTOR
0.17196
 -0.2103 0.5118 0.0340 0.5444
0.61152
0.99425
HCC1419 Ceritinib
ALK
RTK
2.6149
 -0.8670 0.2083 0.0855 2.5745
4.0066
0.99248
HCC1419 Neratinib
EGFR/HER2
RTK
0.0011485
 -0.5015 0.9927 0.1818 0.5367
0.0038194
0.97246
HCC1419 Tivantinib
MET
RTK
0.47955
 0.1634 0.2618 0.0408 2.6512
0.40663
0.98985
HCC1419 Cediranib
VEGFR/cKIT
RTK
5.0599
 -0.0329 0.0545 0.0124 4.9952
5.1984
0.99032
HCC1419 Cabozantinib
VEGFR2/MET
RTK
10.7779
 0.6224 -0.0111 -0.0016 5.0000
12.9768
0.90031
HCC1500 Abemaciclib
CDK4/6
Cell cycle
0.53346
 0.2196 0.3452 -0.0085 0.4860
0.1477
0.84102
HCC1500 Palbociclib
CDK4/6
Cell cycle
Inf
 0.5744 0.1570 0.0053 2.6346
0.039317
0.93709
HCC1500 AZD7762
CHK1/2
Cell cycle
0.035943
 -0.2559 0.6218 0.1217 1.0434
0.037616
0.91391
HCC1500 Volasertib
PLK
Cell cycle
0.011592
 0.2861 0.3454 0.0484 5.0000
0.0099361
0.97732
HCC1500 Dinaciclib
pan CDK
Cell cycle
0.013792
 -0.5720 0.6616 0.1978 2.3762
0.018927
0.99749
HCC1500 Cisplatin
Chemo
Chemotherapy
3.4531
 0.2076 0.1210 -0.0094 5.0000
3.1071
0.92762
HCC1500 Doxorubicin
Chemo
Chemotherapy
0.016258
 -0.7134 0.7518 0.1833 0.7212
0.058468
0.98572
HCC1500 Taxol
Chemo
Chemotherapy
0.0038131
 -0.0589 0.6182 0.1433 1.8138
0.0038924
0.96247
HCC1500 Topotecan
Topo I
Chemotherapy
0.0054632
 -0.8011 1.2171 0.1857 0.7137
0.022012
0.99509
HCC1500 Etoposide
Topo II
Chemotherapy
1.4287
 -0.0766 0.2499 -0.0148 1.3319
1.7871
0.95725
HCC1500 Dasatinib
BCR/ABL
MAPK/nRTK
0.0034818
 -0.1594 0.9249 0.0829 0.7537
0.0052374
0.99634