Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1395 Ceritinib
ALK
RTK
1.6025
 -0.6268 0.2363 0.0809 1.8434
2.6534
0.99554
HCC1395 Neratinib
EGFR/HER2
RTK
0.95453
 0.0167 0.1503 0.0198 0.8768
3.3415
0.98547
HCC1395 Tivantinib
MET
RTK
0.47525
 -0.4835 0.4006 0.1208 1.5047
0.75467
0.99624
HCC1395 Cediranib
VEGFR/cKIT
RTK
1.571
 -0.4825 0.2460 0.0671 1.0270
4.579
0.97022
HCC1395 Cabozantinib
VEGFR2/MET
RTK
5.5518
 0.1138 0.0722 0.0131 1.6522
9.2961
0.98977
HCC1419 Abemaciclib
CDK4/6
Cell cycle
0.10375
 0.2278 0.4350 -0.0030 0.6549
0.0234
0.9117
HCC1419 Palbociclib
CDK4/6
Cell cycle
0.48725
 0.4414 0.2239 -0.0054 1.2398
0.053717
0.97241
HCC1419 AZD7762
CHK1/2
Cell cycle
0.068618
 -0.0826 0.5614 0.1156 2.0553
0.072481
0.98917
HCC1419 Volasertib
PLK
Cell cycle
0.020718
 0.0685 0.3636 0.0462 1.8241
0.018178
0.98538
HCC1419 Dinaciclib
pan CDK
Cell cycle
0.026695
 -0.4761 0.5131 0.1238 5.0000
0.030191
0.99589
HCC1419 Cisplatin
Chemo
Chemotherapy
1.7988
 0.0949 0.2293 0.0086 1.0769
2.0814
0.93793
HCC1419 Doxorubicin
Chemo
Chemotherapy
0.025082
 -0.4663 0.5904 0.0473 0.5199
0.10425
0.94593
HCC1419 Taxol
Chemo
Chemotherapy
0.0052608
 0.2143 0.4700 0.0981 2.1841
0.0040283
0.97754
HCC1419 Topotecan
Topo I
Chemotherapy
0.0071886
 -0.7857 0.9904 0.1711 0.4002
0.11192
0.94532
HCC1419 Etoposide
Topo II
Chemotherapy
0.73579
 0.0317 0.3201 0.0034 1.8770
0.70309
0.96133
HCC1419 Dasatinib
BCR/ABL
MAPK/nRTK
0.82399
 -0.1962 0.3189 0.0194 0.7548
2.3816
0.99358
HCC1419 Trametinib
MEK
MAPK/nRTK
0.031029
 0.4259 0.2875 -0.0031 1.4893
0.0089457
0.98063
HCC1419 Saracatinib
SRC
MAPK/nRTK
0.91888
 -0.1146 0.2758 0.0128 0.8021
1.8388
0.98394
HCC1419 ABT-737
Bcl2/XL
Misc
9.84
 0.4715 0.0022 0.0163 5.0000
11.4973
0.95757
HCC1419 Vorinostat
HDAC
Misc
1.735
 -0.2557 0.1917 0.0407 2.1116
2.1704
0.99173
HCC1419 Luminespib
HSP90
Misc
0.0069643
 -0.2968 0.6506 0.1579 2.0439
0.0087353
0.99699
HCC1419 A-1210477
Mcl-1
Misc
14.536
 0.7081 0.0402 0.0018 1.8053
26.3399
0.8672
HCC1419 Olaparib
PARP
Misc
Inf
 0.6322 0.0273 -0.0012 2.1535
5.2752
0.95353
HCC1419 Bleomycin
Radiation
Misc
4.4662
 0.3545 0.1588 -0.0001 0.8100
4.0786
0.85928
HCC1419 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5051 0.1071 0.0007 1.4251
0.82031
0.95841