Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-134-VI Olaparib
PARP
Misc
Inf
 0.5510 0.0145 -0.0006 4.9904
4.9955
0.86393
MDA-MB-134-VI Bleomycin
Radiation
Misc
1.7911
 0.0193 0.2734 0.0108 0.5040
15.841
0.87961
MDA-MB-134-VI Ipatasertib
AKT
PI3K/mTOR
8.0392
 0.4925 0.0150 0.0096 4.9968
3.7717
0.94642
MDA-MB-134-VI Alpelisib
PI3Ka
PI3K/mTOR
Inf
 0.5331 0.0625 0.0075 2.3500
2.8559
0.92762
MDA-MB-134-VI Taselisib
PI3Ka, g, d
PI3K/mTOR
0.90746
 -0.5146 0.3883 0.0576 0.7496
3.9293
0.88898
MDA-MB-134-VI TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8589 -0.0381 -0.0029 0.0000
Inf
0.38211
MDA-MB-134-VI Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0051713
 -0.9461 0.8935 0.2182 1.1423
0.01301
0.99597
MDA-MB-134-VI Everolimus
mTOR1
PI3K/mTOR
0.00017047
 -0.2444 1.1669 0.1034 0.5948
0.00034979
0.96485
MDA-MB-134-VI INK-128
mTORC1/2
PI3K/mTOR
0.0033793
 -0.8853 1.2003 0.2512 1.2527
0.007425
0.99747
MDA-MB-134-VI PF-4708671
p70S6K
PI3K/mTOR
11.8417
 0.7092 -0.0287 -0.0026 5.0000
12.2595
0.80506
MDA-MB-134-VI Buparlisib
pan PI3K
PI3K/mTOR
0.15425
 -0.8251 0.6432 0.1617 0.9833
0.45209
0.98862
MDA-MB-134-VI Pictilisib
pan PI3K
PI3K/mTOR
2.6892
 -0.1516 0.1775 0.0232 0.9649
8.3966
0.94749
MDA-MB-134-VI Ceritinib
ALK
RTK
0.13159
 -0.9992 0.6654 0.1723 0.9173
0.43587
0.98922
MDA-MB-134-VI Neratinib
EGFR/HER2
RTK
1.1559
 -0.0388 0.0807 0.0241 3.1061
1.2211
0.98626
MDA-MB-134-VI Tivantinib
MET
RTK
0.15045
 -0.6776 0.6505 0.1737 2.2582
0.21541
0.99657
MDA-MB-134-VI Cediranib
VEGFR/cKIT
RTK
4.2103
 -0.9999 0.0977 0.0979 5.0000
5.2449
0.99321
MDA-MB-134-VI Cabozantinib
VEGFR2/MET
RTK
10.9194
 0.6362 -0.0167 -0.0063 5.0000
12.725
0.88168
MDA-MB-157 Abemaciclib
CDK4/6
Cell cycle
1.7983
 -0.6042 0.2687 0.0667 1.1925
4.518
0.93286
MDA-MB-157 Palbociclib
CDK4/6
Cell cycle
Inf
 0.9754 0.0019 0.0010 0.0000
Inf
0.023059
MDA-MB-157 AZD7762
CHK1/2
Cell cycle
0.015418
 -0.7858 0.9840 0.3122 0.8223
0.045445
0.98837
MDA-MB-157 Volasertib
PLK
Cell cycle
0.0069232
 -0.6644 0.8547 0.2325 4.1331
0.0084606
0.99754
MDA-MB-157 Dinaciclib
pan CDK
Cell cycle
0.017724
 -0.9106 0.7675 0.3195 3.8857
0.023072
0.99901
MDA-MB-157 Cisplatin
Chemo
Chemotherapy
5.2381
 0.1885 0.1168 0.0072 1.3335
8.7509
0.97923
MDA-MB-157 Doxorubicin
Chemo
Chemotherapy
0.0032329
 -0.7766 0.9661 0.1885 0.9535
0.006701
0.93404
MDA-MB-157 Taxol
Chemo
Chemotherapy
0.002046
 -0.6700 0.9482 0.3487 1.9966
0.0029397
0.97064