Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
SK-BR-3 Cisplatin
Chemo
Chemotherapy
5.1075
 0.2490 0.0978 0.0114 1.4151
5.7965
0.99044
SK-BR-3 Doxorubicin
Chemo
Chemotherapy
0.0067336
 -0.6156 0.9421 0.3142 1.5278
0.010801
0.99572
SK-BR-3 Taxol
Chemo
Chemotherapy
0.0019068
 -0.3401 0.8905 0.3665 2.3888
0.0023578
0.96349
SK-BR-3 Topotecan
Topo I
Chemotherapy
0.016549
 -0.2711 0.7941 0.1919 1.9350
0.01923
0.98214
SK-BR-3 Etoposide
Topo II
Chemotherapy
0.39826
 -0.3169 0.4040 0.1186 1.5701
0.532
0.99524
SK-BR-3 Dasatinib
BCR/ABL
MAPK/nRTK
3.6452
 0.0810 0.0617 0.0233 5.0000
3.5272
0.98252
SK-BR-3 Trametinib
MEK
MAPK/nRTK
Inf
 0.6828 0.1817 0.0154 1.1257
0.0059643
0.93505
SK-BR-3 Saracatinib
SRC
MAPK/nRTK
4.9166
 0.2786 0.0221 0.0102 5.0000
4.2128
0.96696
SK-BR-3 ABT-737
Bcl2/XL
Misc
Inf
 0.9470 -0.0148 0.0045 0.0000
Inf
0.12804
SK-BR-3 Vorinostat
HDAC
Misc
0.7625
 -0.6322 0.3637 0.1534 2.3291
1.0657
0.99404
SK-BR-3 Luminespib
HSP90
Misc
0.0022783
 -0.0766 0.7140 0.1099 2.5203
0.0024311
0.9977
SK-BR-3 A-1210477
Mcl-1
Misc
11.3859
 0.6275 0.0389 0.0040 4.3303
10.9082
0.92796
SK-BR-3 Olaparib
PARP
Misc
12.0744
 0.5653 0.0429 0.0174 1.0158
35.3887
0.93619
SK-BR-3 Bleomycin
Radiation
Misc
1.0576
 0.1871 0.2604 0.0618 0.8229
0.85134
0.98455
SK-BR-3 Ipatasertib
AKT
PI3K/mTOR
3.3435
 0.3560 0.1553 0.0254 0.8518
1.1231
0.9503
SK-BR-3 Alpelisib
PI3Ka
PI3K/mTOR
0.48468
 -0.1428 0.3788 0.0660 0.4911
2.8836
0.98115
SK-BR-3 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0061659
 -0.2068 0.8068 0.1477 0.6730
0.0081626
0.97463
SK-BR-3 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.7496 -0.0084 0.0076 4.9846
4.3561
0.86723
SK-BR-3 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0036122
 -0.3416 0.7338 0.1751 1.3620
0.0050857
0.99744
SK-BR-3 Everolimus
mTOR1
PI3K/mTOR
-Inf
 0.1182 0.7944 0.1209 0.1000
6.3064e-07
0.84606
SK-BR-3 INK-128
mTORC1/2
PI3K/mTOR
0.0026508
 -0.5064 0.9712 0.2693 1.0983
0.0044617
0.98817
SK-BR-3 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.7342 0.0214 0.0056 1.2557
6.3033
0.91227
SK-BR-3 Buparlisib
pan PI3K
PI3K/mTOR
0.13982
 -0.3731 0.5845 0.1589 0.9631
0.2774
0.98702
SK-BR-3 Pictilisib
pan PI3K
PI3K/mTOR
0.11448
 -0.1267 0.5120 0.0731 0.6701
0.17544
0.99532
SK-BR-3 Ceritinib
ALK
RTK
0.98319
 -0.8254 0.3174 0.0975 1.2454
2.3754
0.98337