Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-231 Vorinostat
HDAC
Misc
1.2388
 -0.3848 0.2821 0.1116 1.7685
1.7699
0.99365
MDA-MB-231 Luminespib
HSP90
Misc
0.0057951
 -0.1782 0.6452 0.2269 3.8625
0.006261
0.99815
MDA-MB-231 A-1210477
Mcl-1
Misc
Inf
 0.9569 0.0519 0.0034 0.0000
Inf
-8.5977e-09
MDA-MB-231 Olaparib
PARP
Misc
14.6165
 0.6179 0.0581 0.0050 0.9419
46.7541
0.98031
MDA-MB-231 Bleomycin
Radiation
Misc
6.333
 0.4365 0.1320 0.0030 1.0810
2.968
0.97684
MDA-MB-231 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.9254 0.0073 -0.0008 0.0000
Inf
0.28623
MDA-MB-231 Alpelisib
PI3Ka
PI3K/mTOR
48.2918
 0.6904 0.0895 0.0045 0.4504
553.5356
0.61498
MDA-MB-231 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.1958
 0.0709 0.2540 0.0294 0.4838
21.2709
0.9085
MDA-MB-231 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8508 0.0154 0.0050 0.6946
20.4646
0.68698
MDA-MB-231 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0251
 -0.0262 0.3856 0.0478 1.0287
0.023885
0.98855
MDA-MB-231 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.7110 0.2246 -0.0006 0.0000
Inf
0.54965
MDA-MB-231 INK-128
mTORC1/2
PI3K/mTOR
0.021834
 0.1013 0.4860 0.0253 1.0516
0.015209
0.98917
MDA-MB-231 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.8544 0.0105 0.0068 4.2838
3.8501
0.8794
MDA-MB-231 Buparlisib
pan PI3K
PI3K/mTOR
1.5103
 -0.2351 0.2751 0.0596 1.9855
1.8969
0.98328
MDA-MB-231 Pictilisib
pan PI3K
PI3K/mTOR
5.3159
 0.3053 0.2062 0.0120 0.3649
107.9707
0.87205
MDA-MB-231 Ceritinib
ALK
RTK
0.86565
 -0.3326 0.3444 0.1014 1.9065
1.1609
0.99581
MDA-MB-231 Neratinib
EGFR/HER2
RTK
1.4329
 -0.0957 0.1056 0.0516 1.6284
2.8124
0.99527
MDA-MB-231 Tivantinib
MET
RTK
0.41694
 -0.0845 0.3330 0.1029 2.2640
0.43275
0.99134
MDA-MB-231 Cediranib
VEGFR/cKIT
RTK
5.0964
 -0.3620 0.1160 0.0659 2.7537
7.595
0.99835
MDA-MB-231 Cabozantinib
VEGFR2/MET
RTK
4.8325
 0.0749 0.1413 0.0336 1.2384
11.7338
0.95871
SK-BR-3 Abemaciclib
CDK4/6
Cell cycle
0.035311
 0.1432 0.5363 0.0387 0.6381
0.016543
0.96857
SK-BR-3 Palbociclib
CDK4/6
Cell cycle
0.17601
 0.3503 0.2849 0.0218 0.9678
0.038204
0.97912
SK-BR-3 AZD7762
CHK1/2
Cell cycle
0.02013
 -0.4509 0.9023 0.2866 3.0174
0.024464
0.99546
SK-BR-3 Volasertib
PLK
Cell cycle
0.0054419
 -0.3494 0.7044 0.2799 4.1140
0.0060939
0.9976
SK-BR-3 Dinaciclib
pan CDK
Cell cycle
0.0068129
 -0.6209 0.8362 0.3009 3.4320
0.008573
0.99807