Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
MDA-MB-157 Cabozantinib
VEGFR2/MET
RTK
2.7778
 0.1490 0.2101 0.0326 0.5335
21.7804
0.97157
MDA-MB-361 Abemaciclib
CDK4/6
Cell cycle
0.0053492
 -0.3418 0.8279 0.0335 0.5371
0.0096902
0.8686
MDA-MB-361 Palbociclib
CDK4/6
Cell cycle
0.019625
 0.1481 0.4822 0.0065 2.1670
0.01672
0.99444
MDA-MB-361 AZD7762
CHK1/2
Cell cycle
0.0076402
 -0.6753 1.0533 0.2116 2.0458
0.010426
0.97675
MDA-MB-361 Volasertib
PLK
Cell cycle
0.0035439
 -0.4972 0.8204 0.1921 4.6311
0.0040451
0.98886
MDA-MB-361 Dinaciclib
pan CDK
Cell cycle
0.011817
 -0.2748 0.6004 0.0836 5.0000
0.013067
0.99187
MDA-MB-361 Cisplatin
Chemo
Chemotherapy
2.6294
 -0.3498 0.1809 0.0253 2.1659
3.6196
0.98908
MDA-MB-361 Doxorubicin
Chemo
Chemotherapy
0.012289
 -0.7224 0.9125 0.1900 2.1676
0.017167
0.96442
MDA-MB-361 Taxol
Chemo
Chemotherapy
0.0031082
 -0.6090 0.9738 0.2561 2.5508
0.0042111
0.9201
MDA-MB-361 Topotecan
Topo I
Chemotherapy
0.011361
 -0.7622 1.1276 0.2239 1.9673
0.01715
0.98983
MDA-MB-361 Etoposide
Topo II
Chemotherapy
1.1915
 -0.5173 0.3432 0.0513 1.6855
1.9175
0.9862
MDA-MB-361 Dasatinib
BCR/ABL
MAPK/nRTK
0.26737
 0.0805 0.3513 0.0255 1.3524
0.20359
0.98324
MDA-MB-361 Trametinib
MEK
MAPK/nRTK
1.0029
 0.5021 0.2191 0.0194 0.4857
0.060413
0.90885
MDA-MB-361 Saracatinib
SRC
MAPK/nRTK
0.42599
 -0.1780 0.4058 0.0330 0.4194
5.848
0.98077
MDA-MB-361 ABT-737
Bcl2/XL
Misc
Inf
 0.8441 -0.0067 0.0094 2.5452
4.5021
0.68512
MDA-MB-361 Vorinostat
HDAC
Misc
0.76224
 -0.9392 0.4607 0.1761 2.2187
1.2401
0.99784
MDA-MB-361 Luminespib
HSP90
Misc
0.0071417
 -0.8855 0.9781 0.3455 4.9987
0.0087421
0.9995
MDA-MB-361 A-1210477
Mcl-1
Misc
Inf
 0.9850 -0.0083 0.0037 0.0000
Inf
-0.045307
MDA-MB-361 Olaparib
PARP
Misc
4.8624
 0.0945 0.1038 0.0095 1.2844
11.0203
0.97233
MDA-MB-361 Bleomycin
Radiation
Misc
0.75794
 -0.2660 0.3607 0.0429 0.8418
1.9803
0.97757
MDA-MB-361 Ipatasertib
AKT
PI3K/mTOR
0.31325
 -0.5798 0.4548 0.0905 0.7404
1.2042
0.98932
MDA-MB-361 Alpelisib
PI3Ka
PI3K/mTOR
0.22264
 -0.7994 0.5323 0.1181 0.6802
1.1196
0.97671
MDA-MB-361 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0017737
 -0.9902 1.4103 0.4329 0.6207
0.010237
0.9975
MDA-MB-361 TGX221
PI3Kb
PI3K/mTOR
13.225
 0.7989 -0.0336 0.0006 4.9995
13.1104
0.64936
MDA-MB-361 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.0050713
 -0.9642 0.8689 0.2561 0.9911
0.014575
0.99687