Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
HCC1937 AZD7762
CHK1/2
Cell cycle
0.166
 -0.3625 0.4881 0.1939 1.0122
0.26931
0.9768
HCC1937 Volasertib
PLK
Cell cycle
0.011931
 -0.1480 0.4968 0.1111 1.6595
0.013417
0.99404
HCC1937 Dinaciclib
pan CDK
Cell cycle
0.021814
 -0.2071 0.4822 0.0817 5.0000
0.02333
0.9981
HCC1937 Cisplatin
Chemo
Chemotherapy
0.7769
 0.0060 0.3266 0.0782 0.6212
1.7561
0.98656
HCC1937 Doxorubicin
Chemo
Chemotherapy
0.012819
 -0.1660 0.5790 0.1786 1.3570
0.012547
0.9584
HCC1937 Taxol
Chemo
Chemotherapy
0.0024514
 0.0104 0.6576 0.2104 2.2541
0.0024561
0.99541
HCC1937 Topotecan
Topo I
Chemotherapy
0.0155
 -0.4282 0.8369 0.2949 0.6712
0.03544
0.94323
HCC1937 Etoposide
Topo II
Chemotherapy
0.35445
 -0.1182 0.3932 0.1412 0.8265
0.49943
0.98817
HCC1937 Dasatinib
BCR/ABL
MAPK/nRTK
0.11264
 0.0153 0.4415 0.1071 1.7303
0.097801
0.98944
HCC1937 Trametinib
MEK
MAPK/nRTK
Inf
 0.6885 0.1384 0.0485 1.0415
0.012758
0.98277
HCC1937 Saracatinib
SRC
MAPK/nRTK
Inf
 0.6508 0.0392 0.0248 1.9114
3.8679
0.97821
HCC1937 ABT-737
Bcl2/XL
Misc
5.7613
 0.2685 0.0849 0.0618 1.0314
14.9529
0.9843
HCC1937 Vorinostat
HDAC
Misc
1.9099
 -0.0085 0.1933 0.0353 1.4929
2.1786
0.99505
HCC1937 Luminespib
HSP90
Misc
0.011448
 -0.1867 0.5478 0.2244 4.8554
0.012181
0.99929
HCC1937 A-1210477
Mcl-1
Misc
Inf
 0.7240 0.0060 0.0046 4.0529
5.9209
0.95858
HCC1937 Olaparib
PARP
Misc
26.5474
 0.6855 0.0584 0.0092 0.6339
150.1948
0.9681
HCC1937 Bleomycin
Radiation
Misc
0.1866
 0.1388 0.4157 0.1325 0.9803
0.14295
0.99691
HCC1937 Ipatasertib
AKT
PI3K/mTOR
Inf
 0.5349 0.1565 0.0058 1.0014
0.36202
0.97156
HCC1937 Alpelisib
PI3Ka
PI3K/mTOR
18.8171
 0.6577 0.0501 0.0085 0.8078
73.2808
0.94623
HCC1937 Taselisib
PI3Ka, g, d
PI3K/mTOR
1.2267
 0.1206 0.2771 0.0422 0.5159
3.7186
0.99159
HCC1937 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8377 0.0202 0.0070 0.6226
52.0493
0.74303
HCC1937 Torin2
mTOR/ATM/ATR
PI3K/mTOR
0.093408
 0.0726 0.2910 0.0569 0.5617
0.18674
0.97982
HCC1937 Everolimus
mTOR1
PI3K/mTOR
Inf
 0.6324 0.3348 0.0206 0.4211
0.00012787
0.92563
HCC1937 INK-128
mTORC1/2
PI3K/mTOR
0.051498
 0.3579 0.3694 0.0196 1.0019
0.011127
0.99251
HCC1937 PF-4708671
p70S6K
PI3K/mTOR
Inf
 0.7688 0.0390 0.0001 0.6190
21.7234
0.88762